Обеспеченность витамином D и метаболические нарушения: систематический анализ фундаментальных и доказательных исследований по проблемам избыточной массы тела и сахарного диабета


О.А. Громова (1, 2), И.Ю. Торшин (2, 3), О.А. Лиманова (1, 2), Т.Р. Гришина (1), А.Н. Громов (3)

(1) ГБОУ ВПО «Ивановская государственная медицинская академия» МЗ РФ, Иваново; (2) Российский сотрудничающий центр Института микроэлементов ЮНЕСКО, Москва; (3) ФГБУН «Вычислительный центр им. А.А. Дородницына» РАН, Москва
Витамин D регулирует метаболизм глюкозы и жиров. Дефицит витамина D ассоциирован с избыточным накоплением жировой ткани, глюкозотолерантностью и инсулинорезистентностью. В настоящей работе приведены результаты фундаментальных и клинических исследований, подтверждающих связь между дефицитом витамина D и формированием глюкозотолерантности, инсулинорезистентности, метаболического синдрома и сахарного диабета. Результаты клинических исследований показывают, что для терапии ожирения и диабета могут быть эффективными дозы витамина D 2000, 4000 МЕ/сут.

Литература



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Об авторах / Для корреспонденции


О.А. Громова – д.м.н., проф. кафедры фармакологии и клинической фармакологии ГБОУ ВПО «Ивановская государственная медицинская академия» МЗ РФ, зам. директора по научной работе Российского центра Института микроэлементов ЮНЕСКО; e-mail: unesco.gromova@gmail.com
И.Ю. Торшин – к.х.н., зав. лабораторией вычислительной и системной биологии ФГБУН Вычислительный центр им. А.А. Дородницына РАН, консультант Российского центра Института микроэлементов ЮНЕСКО
О.А. Лиманова – к.м.н., доцент кафедры фармакологии и клинической фармакологии ГБОУ ВПО «Ивановская государственная медицинская академия» МЗ РФ, научный консультант Российского центр Института микроэлементов ЮНЕСКО
Т.Р. Гришина – д.м.н., проф., ГБОУ ВПО «Ивановская государственная медицинская академия» МЗ РФ
А.Н. Громов – математик-аналитик ФГБУН Вычислительный центр им. А.А. Дородницына РАН


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