This work was aimed to the comparative assessment of the activity of free-radical lipid oxidation in the body of tuberculosis patients and healthy volunteers. The study involved 76 patients with drug-susceptible and drug-resistant pulmonary tuberculosis (mean age 42.97±15.38 years) and 40 relatively healthy volunteers (mean age 42.45±11.56 years). Venous blood samples were used for the study. Malondialdehyde concentration was determined in blood serum (Costa et al. [2006]); the activity of enzymes of the glutathione system – glutathione peroxidase (Paglia et al., [1967]), glutathione-S-transferase (Habig et al. [1974]), glutathione reductase (Mannervik et al. [1978]) and the concentration of reduced glutathione (Tietze et al. [1969]) – was determined in erythrocyte hemolysate According to the results of our study, in the body of patients with tuberculosis, there is an increase in the intensity of free-radical oxidation against the background of a decrease in antioxidant protection. The intensity of free-radical lipid oxidation and the indices of the glutathione system among patients with drug-sensitive and drug-resistant pulmonary tuberculosis did not differ significantly.

Keywords: detoxification of xenobiotics, free-radical lipid oxidation, glutathionereductase, glutathione transferase, reduced glutathione, tuberculosis, glutathione peroxidase