Diagnostic algorithm and reasonable therapy of patients with obstructive sleep apnea and resistant arterial hypertension


DOI: https://dx.doi.org/10.18565/pharmateca.2019.5.138-143

M.V. Gorbunova, S.L. Babak, A.G. Malyavin

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Department of Phthisiology and Pulmonology, Moscow
Background. Obstructive sleep apnea (OSA), being an independent disease, is closely interrelated with comorbid pathology, such as obesity, arterial hypertension (AH), impaired carbohydrate metabolism, dyslipidemia. СРАР-therapy (Continuous Positive Airway Pressure or CPAP therapy) is the fundamental therapeutic doctrine of patients with OSA. However, the effects of CPAP therapy on normalization of blood pressure and dyslipidemia in OSA patients with resistant arterial hypertension (RAH) remain poorly understood and underused in practice of the therapist.
Objective. The purpose of this publication is to demonstrate a reasonable diagnostic and treatment strategy of drug and drug-free treatment of OSA-patients, using the example of a comorbid patient OSA+RAH.
Conclusions. Modern diagnostic algorithms for OSA patients are realistic and workable in everyday medical practice. They allow you to perform a reliable diagnosis of sleep apnea in a hospital or outpatient. Long-term CPAP therapy in patients with OSA+RAH is lifesaving technology with a high compliance and clinical effect. It is necessary to expand the boundaries of the early use of CPAP therapy, especially in OSA patients with comorbid pathology.
Keywords: obstructive sleep apnea, resistant arterial hypertension, carbohydrate metabolism, obesity, comorbid patient, CPAP-therapy

About the Autors


Corresponding author: Sergey L. Babak, MD, Professor, Department of Phthisiology and Pulmonology, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; e-mail: sergbabak@mail.ru
Address: 20, Build. 1, Delegatskaya Street, Moscow 127473, Russian Federation


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