2. Zhang W., Zhang S., Deng Y., et al.; STEP Study Group. Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension. N Engl J Med. 2021 385(14):1268–79. doi: 10.1056/NEJMoa2111437.

3. Фармакотерапия у лиц пожилого и старческого возраста. Клинические рекомендации МЗ РФ, 2018. URL: https://rgnkc.ru/images/metod_materials/Farmakoterapiya_2018.pdf (Pharmacotherapy in elderly and senile people. Clinical recommendations of the Ministry of Health of the Russian Federation, 2018. URL: https://rgnkc.ru/images/metod_materials/Farmakoterapiya_2018.pdf (In Russ.)].

4. Кобалава Ж.Д., Конради А.О., Недогода С.В. и др. Артериальная гипертензия у взрослых. Клинические рекомендации 2020. Российский кардиологический журнал. 2020;25(3):3786. doi: 10.15829/1560-4071-2020-3-3786.

5. Старческая астения. Клинические рекомендации МЗ РФ. URL: https://cr.minzdrav.gov.ru/schema/613_2

6. Visseren F.L.J., Mach F., Smulders Y.M., et al. ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice: Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With the special contribution of the European Association of Preventive Cardiology (EAPC). Rev Esp Cardiol (Engl Ed). 2022;75(5):429. English, Spanish. doi: 10.1016/j.rec.2022.04.003.

7. Mancia G., Kreutz R., Brunstrom M., et al. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023;41(12):1874–2071. doi: 10.1097/HJH.0000000000003480.

8. Warwick J., Falaschetti E., Rockwood K., et al. No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over. BMC Med. 2015;13:78. doi: 10.1186/s12916-015-0328-1.

9. Wang Z., Du X., Hua C., et al. The Effect of Frailty on the Efficacy and Safety of Intensive Blood Pressure Control: A Post Hoc Analysis of the SPRINT Trial. Circulation. 2023;148(7):565–74. doi: 10.1161/CIRCULATIONAHA.123.064003.

10. Benetos A., Labat C., Rossignol P., et al. Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and Mortality in Older Nursing Home Residents: The PARTAGE Study. JAMA Intern Med. 2015 Jun;175(6):989–95. doi: 10.1001/jamainternmed.2014.8012

11. Peng J., Zhao Y., Zhang H., et al. Prevention of metabolic disorders with telmisartan and indapamide in a Chinese population with high-normal blood pressure. Hypertens Res. 2015;38(2):123–31. doi: 10.1038/hr.2014.148

12. Fagard R.H., Staessen J.A. Treatment of isolated systolic hypertension in the elderly: the Syst-Eur trial. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Clin Exp Hypertens. 1999;21(5-6):491–97. doi: 10.3109/10641969909060982.

13. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA. 1991;265(24):3255–64.

14. Gil-Extremera B., Cia-Gomez P. Hypertension in the elderly. Int J Hypertens. 2012;2012:859176. doi: 10.1155/2012/859176.

15. Liang W., Ma H., Cao L., et al. Comparison of thiazide-like diuretics versus thiazide-type diuretics: a meta-analysis. J Cell Mol Med. 2017;21(11):2634–42. doi: 10.1111/jcmm.13205.

16. Roush G.C., Ernst M.E., Kostis J.B., et al. Head-to-head comparisons of hydrochlorothiazide with indapamide and chlorthalidone: antihypertensive and metabolic effects. Hypertension. 2015; 65(5):1041–46. doi: 10.1161/HYPERTENSIONAHA.114.05021.

17. Barrios V., Escobar C. Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control. 2014;7:35–47. doi: 10.2147/IBPC.S40248.

18. McNally R.J., Morselli F., Farukh B., et al. A review of the prescribing trend of thiazide-type and thiazide-like diuretics in hypertension: A UK perspective. Br J Clin Pharmacol. 2019;85(12):2707–13. doi: 10.1111/bcp.14109.

19. Pazan F., Weiss C., Wehling M.; FORTA Expert Panel Members. The EURO-FORTA (Fit fOR The Aged) List Version 2: Consensus Validation of a Clinical Tool for Improved Pharmacotherapy in Older Adults. Drugs Aging. 2023 May;40(5):417–26. doi: 10.1007/s40266-023-01024-6.

20. Lin Z., Cheung B.M.Y., Tang V., Tsoi M.F.. Incidence of severe hypokalaemia in patients taking indapamide. Intern Emerg Med. 2023;18(2):549–57. doi: 10.1007/s11739-023-03209-8.

21. Vinereanu D., Dulgheru R., Magda S., et al. The effect of indapamide versus hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: results of a randomized trial. Am Heart J. 2014;168(4):446–56. doi: 10.1016/j.ahj.2014.06.010.

22. Ripp T.M., Mordovin V.F., Lekarskii S.E. Indapamide retard and enalapril in patients with arterial hypertension: hypotensive effectiveness and effect on endothelial function Kardiologiia. 2007;47(4):45–50.

23. Bulpitt C.J., Webb R., Beckett N., et al. Antihypertensive treatment decreases arterial stiffness at night but not during the day. Results from the Hypertension in the Very Elderly Trial. Blood Press. 2017;26(2):109–14. doi: 10.1080/08037051.2016.1219222.

24. Roush G.C., Abdelfattah R., Song S., et al. Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium-sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta-analysis. J Clin Hypertens (Greenwich). 2018;20(10):1507–15. doi: 10.1111/jch.13386.

25. Puig J.G., Marre M., Kokot F., et al. Efficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes. Am J Hypertens. 2007;20(1):90–7. doi: 10.1016/j.amjhyper.2006.05.018.

26. Wang S, Li J, Zhou X, Liu K, Zhang X, Meng Q, Shi R, Shi D, Chen X. Comparison between the effects of hydrochlorothiazide and indapamide on the kidney in hypertensive patients inadequately controlled with losartan. J Hum Hypertens. 2017;31(12):848–54. doi: 10.1038/jhh.2017.51.

27. Gorelick P.B. Risk factors for vascular dementia and Alzheimer disease. Stroke. 2004;35(11 Suppl 1):2620–22. doi: 10.1161/01.STR.0000143318.70292.47.

28. Ninomiya T., Ohara T., Hirakawa Y., et al. Midlife and late-life blood pressure and dementia in Japanese elderly: the Hisayama study. Hypertension. 2011;58(1):22–8. doi: 10.1161/HYPERTENSIONAHA.110.163055.

29. Hughes D., Judge C., Murphy R., et al. Association of Blood Pressure Lowering With Incident Dementia or Cognitive Impairment: A Systematic Review and Meta-analysis. JAMA. 2020 19;323(19):1934–44. doi: 10.1001/jama.2020.4249.

30. Ou Y.N., Tan C.C., Shen X.N., et al. Blood Pressure and Risks of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of 209 Prospective Studies. Hypertension. 2020;76(1):217–25. doi: 10.1161/HYPERTENSIONAHA.120.14993.

31. Lennon M.J., Lam B.C.P., Lipnicki D.M., et al. Use of Antihypertensives, Blood Pressure, and Estimated Risk of Dementia in Late Life: An Individual Participant Data Meta-Analysis. JAMA Netw Open. 2023;6(9):e2333353. doi: 10.1001/jamanetworkopen.2023.33353.

32. Forette F., Seux M.L., Staessen J.A., et al.; Systolic Hypertension in Europe Investigators. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med. 2002 14;162(18):2046–52. doi: 10.1001/archinte.162.18.2046.

33. Яскевич Р.А., Кочетков А.И., Остроумова О.Д. и др. Оценка влияния нитрендипина на когнитивный статус больных старших возрастных групп с артериальной гипертонией. Сборник тезисов XIII международного конгресса «Кардиология на перекрестке наук», Тюмень, 2023. C. 384–88.

34. Applegate W.B., Pressel S., Wittes J., et al. Impact of the treatment of isolated systolic hypertension on behavioral variables. Results from the systolic hypertension in the elderly program. Arch Intern Med. 1994;154(19):2154–60.

35. Lithell H., Hansson L., Skoog I., et al.; SCOPE Study Group. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens. 2003;21(5):875–86. doi: 10.1097/00004872-200305000-00011.

36. Tzourio C., Anderson C., Chapman N., et al.; PROGRESS Collaborative Group. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med. 2003;163(9):1069–75. doi: 10.1001/archinte.163.9.1069.

37. Peters R., Beckett N., Forette F., et al.; HYVET investigators. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol. 2008;7(8):683–89. doi: 10.1016/S1474-4422(08)70143-1.

38. Ostroumova T.M., Ostroumova O.D., Parfenov V.A., et al. Effect of Perindopril/Indapamide on Cerebral Blood Flow in Middle-Aged, Treatment-Naïve Patients with Hypertension. Adv Ther. 2020;37(12):4930–43. doi: 10.1007/s12325-020-01515-7.

39. Michaels N.J., Lemmon K., Plemel J.R., et al. Aging-Exacerbated Acute Axon and Myelin Injury Is Associated with Microglia-Derived Reactive Oxygen Species and Is Alleviated by the Generic edication Indapamide. J Neurosci. 2020;40(44):8587–600. doi: 10.1523/JNEUROSCI.1098-20.2020.