The literature review is devoted to the problems of treating arterial hypertension (AH) in elderly and old patients. The features of examination of elderly patients, goals and strategy of treatment are considered. The literature data on groups of antihypertensive drugs recommended for the treatment of older age groups and the available evidence base are analyzed. The review focuses on the use of indapamide as a drug from the diuretic group, which has an optimal ratio of efficacy and safety. This drug has the optimal class of recommendations for the treatment of the elderly according to the FORTA system. According to meta-analyses, indapamide is characterized by a higher efficiency in reducing systolic blood pressure (SBP; -5.1 mm Hg compared to hypothiazide) and a lower risk of electrolyte disturbances, especially in non-retarded form. The cardio-, nephro- and angioprotective properties of indapamide are described in detail. The possibilities of dementia prevention and possible mechanisms of neuroprotection during treatment with indapamide are discussed.

Keywords: senile asthenia, indapamide, diuretics, arterial hypertension, dementia