Ивабрадин против бисопролола у больных хронической сердечной недостаточностью и сохраненной фракцией выброса левого желудочка


С.Г. Канорский, Ю.В. Борисенко

Кафедра терапии № 2 факультета повышения квалификации и профессиональной переподготовки специалистов ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России, Краснодар
В проспективном рандомизированном исследовании 126 больных хронической сердечной недостаточностью с фракцией выброса левого желудочка ≥50 % на фоне артериальной гипертензии и ишемической болезни сердца во всех случаях применяли фиксированную комбинацию периндоприл/амлодипин, к которой добавляли бисопролол (n=62) или ивабрадин (n=64). Оценка клинического статуса, толерантности к физической нагрузке, качества жизни, уровня N-концевого предшественника мозгового натрийуретического пептида в крови, параметров эхокардиографии проведена исходно и через 12 месяцев терапии. В отличие от бисопролола ивабрадин существенно повышал толерантность больных к физической нагрузке, улучшал качество жизни, снижал уровень N-концевого предшественника мозгового натрийуретического пептида, улучшал эхокардиографические показатели активного расслабления и податливости левого желудочка. По сравнению с бисопрололом ивабрадин имеет преимущества при лечении больных хронической сердечной недостаточностью с сохраненной фракцией выброса левого желудочка на фоне артериальной гипертензии и ишемической
болезни сердца.

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Об авторах / Для корреспонденции


Автор для связи: С.Г. Канорский – д.м.н., проф., зав. кафедрой терапии № 2 ФПК и ППС ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России; e-mail: kanorskysg@mail.ru


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