Пробиотические штаммы лактобацилл как фактор комплексной терапии и профилактики разных состояний и заболеваний у детей


Н.И. Урсова

Кафедра и клиника педиатрии Московского областного научно-исследовательского клинического института им. М.Ф. Владимирского, Москва
В статье рассматриваются современные воззрения на проблему профилактического и терапевтического применения лактосодержащихпробиотиков при самых разных состояниях и заболеваниях. Представлен наиболее значимый, с точки зрения интерниста, систематический анализ физиологических эффектов пробиотического штамма L. rhamnosusGG, имеющий мощное научное досье.

Литература



  1. Walter J. Ecological role of lactobacilli in the gastrointestinal tract: implication for fundamental and biomedical research. Appl Envir Microbiol. 2008;74(16):4985–96.

  2. Yuki N., Shimazaki T., Kushiro A., et al. Colonization of the stratified squamous epithelium of the nonsecreting area of horse stomach by lactobacilli. Appl Environ Microbiol 2000;66(11):5030–34.

  3. Edelman S., Westerlund-Wikstrom B., Leskela S., et al. In vitro adhesion specificity of indigenous Lactobacilli within the avian intestinal tract. Appl Environ Microbiol 2000;68(10):5155–59.

  4. Dunne C. Adaptation of bacteria to the intestinal niche: probiotics and gut disorder. Inflamm bowel dis 2001;7(1):136–45.

  5. Бондаренко В.М. Обоснование и тактика назначения в медицинской практике различных форм пробиотических препаратов. Фарматека. 2012;13:89–99.

  6. Mercenier A., Pavan S., Pot B. Probiotics as biotherapeutic agent: present khuwledge and future prospects. Curr. Pharm. Des. 2003;9:175–91.

  7. Fons M., Gomez A., Karjalainen T. Mechanisms of colonization and colonization resistance of the digestive tract. Microbial. Ecol. Health Dis. Sup. 2000;2:240–46.

  8. Miettinen M., Vuiopio-Varkila J., Varkila K. Production of humah tumor necrosis factor alpha interleukin-6 and interleukin-10 is induced by lactic acid bacteria. Infect Immun. 1996;12:5403–405.

  9. Konstantinov S.R., Poznanski E., Fuentes S., et al. Lactobacillus sobrius sp. Nov., a novel isolate abundant in the intestine of weaning piglets. Int. J. Syst. Evol. Microbiol. 2005.

  10. Alakomi H.L., Skytta E., Saarela M., et al. Lactic acid permebilizes gram-negative bacteria by disrupting the outer membrane. Applied Environ Microbiol. 2000;66:2001–05.

  11. Pan X., Chen F., Wu T., et al. The acid, bile tolerance and antimicrobial property of Lactobacillus acidophilus NIT. Food Control 2008;doi:10.1016/j.foodcont.2008.08.019.

  12. Chapman T.M., Plosker G.L., Figgitt D.P. VSL#3 probiotic mixture: a review of its use in chronic inflammatory bowel diseases. Drugs. 2006;66(10):1371–87.

  13. Rachmilevitz D., Katakura K., Karmeli F., et al. Toll-like receptor 9 signaling mediates the anti-inflammatory effect of probiotics murine experimental colitis. Gastroenterol. 2004;126(2):520–28.

  14. O’Sullivan DюJ. Screening of intestinal microflora for effective probiotic bacteria. J. Ag. Food Chem. 2001;49:1751–60.

  15. Schell MA., Karmirantzou M., Snel B., et al. The genome sequence of Bifidobacterium longum reflect its adaptation to the human gastrointestinal tract. Proc. Natl. Sci. USA 2002;99(22):14422–27.

  16. Chavez AюM., Menconi MJ., Hodin RA., et al. Cytokine-induced intestinal epithelial hyperpermeability: role of nitric oxide. Crit. Care Med. 1999;27:2246–51.

  17. Han X., Fink MюP., Delude RюL., et al. Proinflammatory cytokines cause NO-dependent and independent changes in expression and localization of tight junction proteins in intestinal epithelial cells. Shock. 2003;19:229–37.

  18. Marcinkiewicz J., Chain B., Nowak B., et al. Antimicrobal and cytotoxic activity of hypochlorous acid: interactions with taurine and nitrite. Inflam. Res. 2000;49:280–89.

  19. Agorreta J., Garayoa M., Montuenga L.M., Zulueta J.J. Effects of acute hypoxia and lipopolysaccharide on nitric oxide synthase-2 expression in acute lung injury. Am. J. Respir. Crit. Care Med. 2003;168:287–96.

  20. Lundberg J.O., Weitzberg E., Cole J.A., et al. Nitrate, bacteria and human health. Nat. Rev. Microbiol. 2004;2:593–602.

  21. Sobko T., Reinders C.L., Jansson E.A, et al. Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite. Nitric Oxide. 2005;13:163–69.

  22. Tannock G.W. Molecular assessment of intestinal microflora. Am. J. Clin. Nutr. 2001;73:410–14.

  23. Van der Waaij D. Colonization resistance of the Digestive Tract. Japan, 1999. P. 76–81.

  24. Oksaharju A., Kankainen M., Kekkonen R.A., et al. Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cell. World J. Gastroenterol. 2011;17:750–59.

  25. Ouwehand A.C., Isolauri E., Kirjavainen P.V., et al. The mucus binding of B. lactis Bb12 is enhanced in the presence of LGG and L. delbrueckii subsp. bulgaricus. Lett. Appl. Microbiol. 2000;30:10–3.

  26. Ouwehand A.C., Suomalainen T., Tolkko S., Salminen S. In vitro adhesion of propionoc acid bacteria to human intestinal mucus. Lait. 2002;82:123–30.

  27. Урсова Н.И. Дисбактериозы кишечника в детском возрасте: инновации в диагностике, коррекции и профилактике. Руководство для врачей. М., 2013. 328с.

  28. Macfariane S. Microbial biofilm communities in the gastrointestinal tract. J. Clin. Gastroenterol. 2008;242(3):S142–43.

  29. Tannock G.W., Fuller R., Smith S.L., Hall M.A. Plasmid profiling of members of the family enterobacteriaceae, lactobacilli, and bifidobacteria to study the transmission of bacteria from mother to infant. J. Clin. Microbiol. 1990;28:1225–28.

  30. Miller M.B., Bassler B.I. Quorum sensing in bacteria. Annu Rev Microbiol 2001;55:165–99.

  31. Harmsen H.J., Wildeboer-Veloo A.C., Raangs G.С., et al. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J. Pediatr. Gastroenterol. Nutr. 2000;30:61–7.

  32. Adlerberth I., Cerqueti M., Poilane I., Wold A., Collignon A. Mechanisms of colonization and colonization resistance of the digestive tract. Part 1. Bacteria/Host interactions. Microbial. Ecol. Health Dis. 2000;(suppl 2):223–39.

  33. Resta-Lenert S., Barrett K. Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli. Gut. 2003;52:988–97.

  34. Putaala H., Salusjarvi T. Effect of four probiotic strains and Echerichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression. Res Microbiol 2008;doi:10.1016/j.resmic.2008.08.002.

  35. Dethlefsen L., Eckburg PB., Bik E.M., Relman D.A. Assembly of the human intestinal microbiota. Trends Ecol. Evol. 2006;21:517–23.

  36. Deplancke B., Gaskins H.R. Microbial modulation of innate defense: goblet cell and the intestinal mucus layer. Am. J. Clin. Nutr. 2001;73:1131S–41S.

  37. Железная Л.А. Структура и функция гликопротеинов слизи (муцинов). Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 1998;VIII(1):30–7.

  38. Swidsinski A., Loening-Baucke V., Verstraelen H., et al. Biostructure of fecal microbiota in healthy subjects and patients with chronic idiopathic diarrhea. Gastroenterology. 2008;135:568–79.

  39. Gill H.S. Probiotic to enhance anti-infective defenses in the gastrointestinal tract. Best Pract. Res. Clin. Gastroenterol. 2003;17:755–73.

  40. Imazumi R., Hirata K., Zommara M., et al. Effects of cultered mile products by Lactobacillus and Bifidobacterias species on secretion of the bile acids in hepatocytes and in rats. J. Nutr. Sci. Vitaminol (Tokio). 1992;4:186–91.

  41. Konstantinov S.R., Poznanski E., Fuentes S., et al. Lactobacillus sobrius sp. Nov., a novel isolate abundant in the intestine of weaning piglets. Int. J. Syst. Evol. Microbiol. 2005.

  42. Montrose D.S., Floch M.H. Probiotics used in human studies. J. Clin. Gastroenterol. 2005;39(6):469–84.

  43. Кафарская Л.И., Шуникова М.Л., Ефимов Б.А., Шкопоров А.Н. и др. Особенности формирования микрофлоры у детей раннего возраста и пути ее коррекции с помощью пробиотиков. Вопросы современной педиатрии. 2011;2:94–8.

  44. Lebeer S., Vanderleydes G., De Keersmaecker SC. Genes and molecules of lactobacillus supporting probiotic action. Microbiol. Mol. Biol. Rev. 2008;72:728–64.

  45. Perdigon G., Fuller R., Raya R. Lactis acid bacteria and their effect on the immune system. Curr. Issues Intest. Microbiol. 2001;2(1):27–42.

  46. Sun J., Shi J.H., Le G.W., et al. Distinct immune response induced by peptidoglycan derived from Lactobacillus spp. World J. Gastroenterol. 2005;11(40):6330–37.

  47. Cummings J.H., Macfarlan G.T. The control and conseguences of bacterial fermentation in the human colon. J. Appl. Bacteriol. 1991;70:443–59.

  48. Fregeau G.J., Helgason C.D., Bleackley R.C. Two cytotoxic cell proteinase genes are differently sensitive to sodium butyrate. Nucleic Acids Res. 1992; 20:3113–19.

  49. Gibson G.R., Macfarlane S., Macfarlane G.T. Metabolic interactions involving sulphate-reducing and methanogenic bacteria in the human large intestine. FEMS Microbiol. Ecol. 1993;12:117–25.

  50. Florin T.H., Jabbar I.A. A possible role for bile acid in the control of methanogenesis and the accumulation of hydrogen gas in the human colon. J. Gastroenterol. Hepatol. 1994;9:112.

  51. Salvioli B., Serra J., Azpiroz F., et al. Tolerance of ileal and colonic gas loads in patients with irritable bowel syndrome and functional bloating. Gastroenterology. 2001;120:A755.

  52. Stark P.L., Lee A. The microbial ecology of the large bowel of breast-fed and formula-fed infants during the first year of life. J. Med. Microbiol. 1982;15 (2):189–203.

  53. Benno Y., Sawada K., Mitsuoka T. The intestinal microflora of infantis: Composition of all flora in breast-fed and bottle-fed infants. Vicrobiol. Immunol. 1984;28:975–86.

  54. Костоломова Г.А. Клинико-иммунологический анализ дисбиотических состояний у детей. Дисс. канд. мед. наук. Тюмень, 2001. 25 с.

  55. Кузнецова Г.Г. Оценка дисбиотических отклонений в кишечной микрофлоре. Тезисы докладов научно-практического семинара «Индивидуальные подходы к проблеме дисбактериоза». М., 2003. С. 19–25.

  56. Лыкова Е.А. Микроэкологические и иммунобиологические нарушения и обоснование применения пробиотиков при инфекционной патологии у детей. Дисс. докт. мед. наук. М., 2000. 44 с.

  57. Harmsen H.J., Wildeboer-Veloo A.C., Raangs Gc., et al. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J. Pediatr. Gastroenterol. Nutr. 2000;30:61–7.

  58. Harmsen H.J., Wildeboer-Veloo A.C., Grijpstra J., Knol J., et al. Development of 16s rRNA-based probes for the Coriobacterium group and the Atopobium cluster and their application for enumeration of Coriobacteriaceae in human feces from volunteers of different age groups. Appl Environ Microbiol. 2000;66:4523–27.

  59. Fons M., Gomez A., Karjalainen T. Mechanisms of colonization and colonization resistance of the digestive tract. Microbial. Ecol. Health Dis. Sup. 2000;2:240–46.

  60. Копанев Ю.А., Соколов А.Л. Дисбактериоз кишечника: микробиологические, иммунологические и клинические аспекты микроэкологических нарушений у детей. М., 2002. 148 с.

  61. Holzapfel W.H., Haberer P., Geisen R., et al. Taxonomy and important features of probiotic microorganisms in food and nutrition. Am. J. Clin. Nutr. 2001;73:365–73.

  62. Lee Y.K., Lim C.Y., Teng W.L., et al. Quantitative approach in the study of adhesion of lactic acid bacteria to intestinal cells ant their competition with enterobacteria. Appl Envir Microbiol. 2000;66(9):3692–97.

  63. O’Sullivan D.J. Screening of intestinal microflora for effective probiotic bacteria. J. Ag Food Chem. 2001;49:1751–60.

  64. Schell M.A., Karmirantzou M., Snel B., et al. The genome sequence of Bifidobacterium longum reflect its adaptation to the human gastrointestinal tract. Proc. Natl. Sci. USA 2002;99(22):14422–27.

  65. Tannock G.W. Molecular assessment of intestinal microflora. Am. J. Clin. Nutr. 2001;73:410–14.

  66. Lievin V., Peiffer I., Hudauit S., et al. Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity. Gut. 2000;47:646–52.

  67. Huang Y., Shao X.M., Neu J. Immunonutrients and neonates. Eur. J. Pediatr. 2003;162:122–28.

  68. Allen S.J., Okoko B., Martinez E., Gregorio G., Dans LF. Probiotics for treating infectious diarrhoea. Cochrane Database Syst. Rev. 2004;(2):CD003048.

  69. Van Niel C.W., Feudtner C., Garrison M.M., et al. Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis. Pediatrics. 2002;109:678–84.

  70. Johnston B.C., Supina A.L., Vohra S. Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials CMAJ. 2006;175(4):377–83.

  71. Johnston B.C., Supina A.L., Ospina M., et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2007;(2):CD004827.

  72. D’Souza A.L., Rajkumar C., Cooke J., et al. Probio-tics in prevention of antibiotic-associated diarrhea: meta-analysis BMJ. 2002;324(7350):1361.

  73. Szajewska H., Ruszczynski M., Radzikowski A. Probiotics in the prevention antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials. J. Pediatr. 2006;149(3):367–72.

  74. Zoppi G., Cinquetti M., Benini A., Bonamini E., Minelli E. Modulation of the intestinal ecosystem by probiotics and lactulose in children during treatment with ceftriaxone. Curr Therap Res 2001;62:418–35.

  75. Sykora J., Valeckova K., Amlerova J., et al. Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114001 and the eradication Helicobacter pylori in children: prospective randomized double-blind study. J. Clin. Gastroenterol. 2005;39:692–98.

  76. Canducci F., Armuzzi A., Cremonini F., et al. A lyophilized and inactivated culture of Lactobacillus acidophilus increases Helicobacter pylori eradication rates. Aliment Pharmacol. Ther. 2000;14:1625–29.

  77. Sheu B.S., Wu J.J., Lo C.Y., et al. Impact of supplement with Lactobacillus and Bifidobacterium containing yogurt on triple therapy for Helicobacter pylori eradication. Aliment Pharmacol. Ther. 2002;16:1669–75.

  78. Wang K.Y., Li S.N., Liu C.S., et al. Effects of ingesting Lactobacillus and Bifidobacterium containing yogurt in subjects with colonized Helicobacter pylori. Am. J. Clin. Nutr. 2004;80:737–41.

  79. Myllyluoma E., Veijola L., Ahlroos T., et al. Probiotic supplementation improves tolerance to Helicobacter pylori eradication therapy – a placebo-controlled, double-blind randomized pilot study. Aliment Pharmacol. Ther. 2005;21:1263–72.


Об авторах / Для корреспонденции


Н.И. Урсова – руководитель педиатрического отделения МОНИКИ им. М.Ф. Владимирского, профессор кафедры педиатрии ФУВ МОНИКИ, главный детский гастроэнтеролог МЗ МО


Похожие статьи


Бионика Медиа