Optimization Of Insulin Therapy Of Type 1 Diabetes Mellitus In The Period Of Pregnancy

I.Yu. Demidova, E.P. Melnikova, N.Yu. Arbatskaya, N.G. Ignatova

Optimization of insulin therapy of type 1 diabetes mellitus in the period of pregnancy
We present the results of the study, including 76 pregnant women with type 1 diabetes mellitus, whose goal was to compare the effects of two methods of insulin therapy (IT) - a constant subcutaneous insulin infusion (CSII), and multiple daily subcutaneous injections of insulin (MDSII) - to ensure the compensation of carbohydrate metabolism. It was shown that in pregnancy the CSII method provides more stable compensation of carbohydrate metabolism, reduces the frequency of hypoglycemia episodes and not increases the risk of diabetic ketoacidosis and progression of late vascular complications of diabetes. Decrease of number of injections, the ability to program rate of insulin administration in advance with account of dietary habits, gestation course, and in accordance with the physical stress and daily schedule leads to significant improvement of quality of the pregnant woman's life at such a crucial period, but also motivate a more careful self-monitoring and correction IT. Thus, the insulin pump therapy is the best and safety way to insulin administration during pregnancy, provides a stable compensation of carbohydrate metabolism and improves pregnancy outcomes.

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