Current approaches to the treatment of acute rhinosinusitis in children in outpatient practice


DOI: https://dx.doi.org/10.18565/pharmateca.2025.7.31-38

Karpova E.P., Belov V.A., Asmanov A.I., Tulupov D.A., Naumov O.G.

1) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 2) Veltischev Research Clinical Institute of Pediatrics and Pediatric Surgery, Pirogov Russian National Research Medical University, Moscow, Russia; 3) Pirogov Russian National Research Medical University, Moscow, Russia; 4) Filatov Children’s City Clinical Hospital, Moscow, Russia
This article briefly describes the main etiological factors, development mechanisms, and traditional approaches to the treatment of rhinosinusitis in children. The emergence of antibiotic-resistant microorganisms is a serious clinical problem associated with more severe disease progression. Acute rhinosinusitis remains a common cause of unnecessary systemic antibacterial therapy. In most cases, antibiotics can be considered overtreatment, as they are completely inappropriate for the treatment of viral infections. When determining the indications for antibacterial therapy, as well as when choosing a specific drug, it is necessary to follow current national clinical guidelines. This article discusses the general principles of rational antibacterial therapy for the treatment of rhinosinusitis in children, the criteria for the selection and use of cephalosporins, in particular cefixime in a dispersible form, which has particular advantages in treating children and ensures high patient compliance due to its high efficacy against most respiratory pathogens, favorable safety profile, convenient administration, and the ability to be administered once daily.
Keywords: cefixime, acute rhinosinusitis, clinical guidelines, children, treatment
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About the Autors

Elena P. Karpova, Dr. Sci. (Med.), Professor, Head of the Department of Pediatric Otolaryngology named after Professor B.V. Shevrygin, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; ORCID: https://orcid.org/0000-0002-8292-9635 (corresponding author)
Vladimir A. Belov, Cand. Sci. (Med.), Assistant Professor, Department of Pediatric Otolaryngology named after Professor B.V. Shevrygin, Russian Medical Academy of Continuous Professional Education; Head of the Otolaryngology Department, Veltischev Research Clinical Institute of Pediatrics and Pediatric Surgery, Pirogov Russian National Research Medical University, Moscow, Russia. ORCID: https://orcid.org/0000-0002-2955-2015
Alan I. Asmanov, Cand. Sci. (Med.), Head of the Department of Acute and Chronic Ear, Nose, and Throat Pathology, Veltischev Research Clinical Institute of Pediatrics and Pediatric Surgery, Pirogov Russian National Research Medical University; Assistant Professor, Otolaryngology Department, Faculty of Pediatrics, Pirogov Russian National Research Medical University, Moscow, Russia; ORCID: https://orcid.org/0000-0002-3116-6447
Denis A. Tulupov, Cand. Sci. (Med.), Associate Professor, Shevrygin Pediatric Otolaryngology Department, , Russian Medical Academy of Continuous Professional Education; Otolaryngologist, Otolaryngology Department, Filatov Children’s City Clinical Hospital, Moscow, Russia; ORCID: https://orcid.org/0000-0001-6096-2082
Oleg G. Naumov, Cand. Sci. (Med.), Associate Professor, Shevrygin Department of Pediatric Otolaryngology, Russian Medical Academy of Continuous Professional Education; Otolaryngologist, Otolaryngology Department, Filatov Children’s City Clinical Hospital, Moscow, Russia; ORCID: https://orcid.org/0000-0002-8243-8385


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