Русский
Results of evaluation of the effect of the photodynamic therapy for involutional changes on anxiety indicators
DOI: https://dx.doi.org/10.18565/pharmateca.2024.4.176-181
Beymanova M.A., Petunina V.V.
1) Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology of the Moscow Healthcare Department, Moscow, Russia; 2) Pirogov Russian National Research University, Moscow, Russia
Objective. Evaluation of the effect of photodynamic therapy (PDT) with Chlorin E6-based photosensitizer (PS) used for the correction of involutional skin changes, on anxiety in a group of patients with a history of basal cell carcinoma (BCC) or actinic keratosis (AK).
Methods. 90 patients with a history of skin tumors were followed-up. Patients were stratified into two groups, the first included women aged 50–60 years, the second – women over 61 years of age. The PS «Khloderm» was used in this work. The patients’ anxiety scores were assessed using Spielberger-Khanin questionnaires. Additionally, questions about personal fear about cancer, fear of loss of external attractiveness were introduced.
Results. In the group of patients over 60 years of age with a history of of non-melanocytic neoplasms, PDT statistically significantly reduced the proportion of high anxiety levels. The levels of situational anxiety after a course of PDT changed, showing a statistically significant increase in the proportion of patients with a low anxiety level – from 42.2 to 66.7. An analysis of the patients’ personal fears after correction using PDT showed that the proportion of women who indicated a fear of loss of external attractiveness significantly decreased from the initial values in the group of patients under 60 years of age. After 1 year after PDT, the proportion of patients who experienced fear of loss of external attractiveness significantly decreased from the baseline, not only in the subgroup under 60 years of age, but also over 60 years of age, which may reflect the accumulated effect of PDT.
Conclusion. Against the background of PDT using LED lamps for the correction of involutional changes, there was a decrease in the indicators of personal fears of patients in terms of both loss of external attractiveness with age and fears associated with the underlying disease, which can be regarded as a normalization of the psychological aspect of quality of life in the presence of a burdened history of cancer.
Methods. 90 patients with a history of skin tumors were followed-up. Patients were stratified into two groups, the first included women aged 50–60 years, the second – women over 61 years of age. The PS «Khloderm» was used in this work. The patients’ anxiety scores were assessed using Spielberger-Khanin questionnaires. Additionally, questions about personal fear about cancer, fear of loss of external attractiveness were introduced.
Results. In the group of patients over 60 years of age with a history of of non-melanocytic neoplasms, PDT statistically significantly reduced the proportion of high anxiety levels. The levels of situational anxiety after a course of PDT changed, showing a statistically significant increase in the proportion of patients with a low anxiety level – from 42.2 to 66.7. An analysis of the patients’ personal fears after correction using PDT showed that the proportion of women who indicated a fear of loss of external attractiveness significantly decreased from the initial values in the group of patients under 60 years of age. After 1 year after PDT, the proportion of patients who experienced fear of loss of external attractiveness significantly decreased from the baseline, not only in the subgroup under 60 years of age, but also over 60 years of age, which may reflect the accumulated effect of PDT.
Conclusion. Against the background of PDT using LED lamps for the correction of involutional changes, there was a decrease in the indicators of personal fears of patients in terms of both loss of external attractiveness with age and fears associated with the underlying disease, which can be regarded as a normalization of the psychological aspect of quality of life in the presence of a burdened history of cancer.
About the Autors
Corresponding author: Maria A. Beimanova, Postgraduate Student at the departm£ent, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology of the Moscow Healthcare Department, Moscow, Russia; beimanova@mail.ru
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