Background. The article describes a case of successful treatment of a patient with Kellgren stage 1–2 knee osteoarthritis with obesity using a combination of methylsulfonylmethane, vitamin C and native collagen-2 as a non-drug treatment method.
Description of the clinical case. In patient M., the dynamics of pain articular syndrome with obesity was analyzed during treatment with a combination of methylsulfonylmethane, vitamin C and native collagen-2 for 60 days. Already on the 20th day of treatment, and fter 60 days, the pain in the joint, stiffness, and crepitus significantly decreased. There was a significant positive dynamics of laboratory, biochemical and ultrasound examination results.
Discussion. This clinical case clearly showed the effectiveness and safety of a combination of methylsulfonylmethane, vitamin C and native collagen-2, the rapid positive dynamics of the symptoms of the disease, results of additional laboratory and instrumental methods of examination.
Conclusion. The combination of methylsulfonylmethane, vitamin C and native collagen-2 can be recommended for use in patients with osteoarthritis in the early stages of the disease.

Keywords: native collagen-2, osteoarthritis, obesity