THE ROLE OF VITAMIN D DEFICIENCY IN THE FORMATION OF OSTEOPENIC SYNDROME IN YOUNG OBESE WOMEN AND WOMEN WITH NORMAL BODY WEIGHT


T.L. Karonova (1, 2), AT Andreeva (1), EV Mokhova (1), M.V. Budanova (1), E.N. Grineva (1, 2)

1) FSBI Northwestern Federal Medical Research Center of the Ministry of RMPH, St.Petersburg; 2) SBEI HPE SPbSMU n.a. Acad. I.P. Pavlov of RMPH, St. Petersburg
The results of studies assessing bone mineral density in obese people are rather inconsistent. The present study was aimed to the identification of indicators of mineralization of the skeleton in women with different body mass to clarify the contribution of vitamin D deficiency in the formation of osteopenic syndrome. The study involved 204 women aged 30 to 52 years (mean age 46.20 ± 0.54 years). Reduced bone mineral density (BMD) at the lumbar spine or proximal femur was found in 38 women (18.6%). It has been established that the 25 (OH) D levels (R2 = 0.25, P = 0.011) and parathyroid hormone levels (R2 = 0.15, P = 0.037) provided the greatest effect on the BMD of the lumbar spine (in women under the age of 40 years); the bone mineral density of proximal femur depended on the body mass index (R2 = 0.21, P = 0.016), waist circumference (R2 = 0.30, P = 0.005), amount of adipose tissue (R2 = 0.28 , P = 0.006) and serum leptin levels (R2 = 0.26, P = 0.043), regardless of the women age. Thus, the study showed that the amount of body fat, vitamin D deficiency and high leptin levels play an important role in bone remodeling in young women.

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About the Autors


T.L. Karonova - Doctor of Medical Sciences, Head of the SRL of Clinical Endocrinology of the Institute of Endocrinology FSBI NWFMRC of RMPH, Associate Professor at the Department of Faculty Therapy with a course of Endocrinology and Clinic SBEI HPE SPbSMU n.a. Acad. I.P. Pavlov of RMPH, St. Petersburg; e-mail: karonova@mail.ru;
A.T. Andreeva - resident physician at the Institute of Endocrinology FSBI NWFMRC of RMPH, St. Petersburg
E.V. Mokhova - postgraduate student at the Institute of Endocrinology FSBI NWFMRC of RMPH, St. Petersburg
M.V. Budanova - Head of the Radiology Department, Junior Researcher at the Institute of Endocrinology FSBI NWFMRC of RMPH, St. Petersburg
E.N. Grineva - Doctor of Medical Sciences, Director of the Institute of Endocrinology FSBI NWFMRC of RMPH, Prof. at the Department of Faculty Therapy with a course of Endocrinology and Clinic SBEI HPE SPbSMU n.a. Acad. I.P. Pavlov of RMPH, St. Petersburg


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