Русский
Modern possibilities for correcting the uric acid level and eliminating skin manifestations of gout
DOI: https://dx.doi.org/10.18565/pharmateca.2022.13.106-109
E.I. Vereshchagin, E.V. Svechnikova, N.O. Artemyeva
1) Novosibirsk State Medical University, Novosibirsk, Russia; 2) Polyclinic № 1 of the Department for Presidential Affairs of the Russian Federation, Moscow, Russia; 3) Clinic for Preventive and Aesthetic Medicine “Body Project”, Moscow, Russia
Background. It is commonly known that elevated blood serum uric acid (UA) levels is the cause of a number of chronic diseases, such as gout, as well as osteoarthritis and uric acid nephritis. As a rule, prolonged hyperuricemia is accompanied by severe skin manifesta- tions, such as pruritus, erythema, and hypersensitivity. However, the use of drugs to correct hyperuricemia, obviously, does not solve this problem. However, as known, a number of plant extracts effectively enhance the UA clearance, helping to reduce its concentration in blood serum and tissues.
Objective. Evaluation of the effectiveness of the herbal composition on the blood serum UA level in patients with initially elevated UA
levels.
Methods. The study involved patients with elevated serum UA levels (more than 350 µmol/l in women and 415 µmol/l in men). A total of 109 patients aged 45–65 years were examined, including 47 men (Group 1) and 62 women (Group 2). Patients kept a routine diet during the study. A plant composition consisting of micronized leaves of meadowsweet (Filipíndula ulmbria) and white birch (Bítula), as well as aspen bark (Pupulus trémula), was used per os at a dose of 500 mg for 30 days.
Results. Taking this herbal composition for a month made it possible to significantly reduce the UA level both in men and women.
Characteristically, this effect persisted 1 month after the end of treatment. Simultaneously with the decrease in UA level, there were positive significant changes in triglyceride and blood sugar levels in patients with initial hypertriglyceridemia and hyperglycemia. Almost 90% of patients indicated the disappearance of such manifestations as itching, erythema and hypersensitivity, 55% - a decrease in the size of tophi. The effect was observed regardless of the location and extent of skin changes.
Conclusion. A plant composition based on meadowsweet (Filipíndula ulmbria), white birch (Bítula) and aspen (Pуpulus trémula) can be recommended for use as a component of functional nutrition or as an independent herbal preparation in patients with elevated UA levels, metabolic syndrome and gout.
Objective. Evaluation of the effectiveness of the herbal composition on the blood serum UA level in patients with initially elevated UA
levels.
Methods. The study involved patients with elevated serum UA levels (more than 350 µmol/l in women and 415 µmol/l in men). A total of 109 patients aged 45–65 years were examined, including 47 men (Group 1) and 62 women (Group 2). Patients kept a routine diet during the study. A plant composition consisting of micronized leaves of meadowsweet (Filipíndula ulmbria) and white birch (Bítula), as well as aspen bark (Pupulus trémula), was used per os at a dose of 500 mg for 30 days.
Results. Taking this herbal composition for a month made it possible to significantly reduce the UA level both in men and women.
Characteristically, this effect persisted 1 month after the end of treatment. Simultaneously with the decrease in UA level, there were positive significant changes in triglyceride and blood sugar levels in patients with initial hypertriglyceridemia and hyperglycemia. Almost 90% of patients indicated the disappearance of such manifestations as itching, erythema and hypersensitivity, 55% - a decrease in the size of tophi. The effect was observed regardless of the location and extent of skin changes.
Conclusion. A plant composition based on meadowsweet (Filipíndula ulmbria), white birch (Bítula) and aspen (Pуpulus trémula) can be recommended for use as a component of functional nutrition or as an independent herbal preparation in patients with elevated UA levels, metabolic syndrome and gout.
Keywords: tophi, skin manifestations of gout, functional nutrition, diabetes mellitus, uric acid, metabolic syndrome, gout
About the Autors
Corresponding author: Evgeny I. Vereshchagin, Doctor of the Highest Qualification Category, Dr. Sci. (Med.), Professor, Head of the Department of Anesthesiology and Intensive Care n.a. Professor I.P. Vereshchagin, Novosibirsk State Medical University, Novosibirsk, Russia; eivv1961@gmail.com
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