Metabolic comorbidity of endometritis after caesarean section


DOI: https://dx.doi.org/10.18565/pharmateca.2023.3.112-118

N.A. Korobkov, N.V. Bakulina, N.V. Borovik

1) North-Western State Medical University n.a. I.I. Mechnikov, St. Petersburg, Russia; 2) Sestroretskaya Multidisciplinary Clinic, St. Petersburg, Russia
Background. The present study is aimed at evaluation of the occurrence of postpartum (postoperative) infection by analyzing the information content of its predictors in patients with a somatic burden for the subsequent development of recommendations for treatment and prevention.
Objective. Assessment of the prevalence and structure of metabolic and endocrine diseases in puerperas with endometritis after caesarean section to determine their prognostic value as an independent predictor of the development of postoperative infectious and inflammatory complications.
Methods. A retrospective study of case histories and data from primary medical documentation of 406 puerperas with endometritis after caesarean section was carried out.
Results. The prevalence of pregravid obesity in puerperas with endometritis was 21.4% (every fifth patient with a BMI ≥30.00 kg/m2). Approximately with the same frequency (20.4%), various disorders of carbohydrate metabolism were diagnosed, gestational diabetes mellitus prevailed in their structure (78.3%). Obesity complicated the course of pregnancy 1.7 times more often in puerperas with endometritis compared with puerperas with an uncomplicated postoperative course (21.4 vs. 12.4%; χ2=8.36; P=0.004), and carbohydrate metabolism disorders – by 2.2 times (20.4 vs. 9.1%; χ2=14.391; P<0.001).
Conclusion. Concomitant metabolic diseases are significant predictors of the development of postoperative infectious and inflammatory complications in obstetrics.

About the Autors


Corresponding author: Nikolay A. Korobkov, Cand. Sci. (Med.), Associate Professor at the Department of Obstetrics and Gynecology n.a. S.N. Davydov, North-Western State Medical University n.a. I.I. Mechnikov, St. Petersburg, Russia; nikolai_korobkov@mail.ru; eLibrary SPIN: 4191-3581


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