NON-ALCOHOLIC FATTY LIVER DISEASE AND CHOLELITHIASIS: A NEW VIEW ON OLD RELATIONSHIPS


DOI: https://dx.doi.org/10.18565/pharmateca.2018.s3.68-74

P.V. Seliverstov, Т.Е. Skvortsova, S.I. Sitkin, V.G. Radchenko

North-Western State Medical University n.a. I.I. Mechnikov, St. Petersburg
Currently, there is no doubt about close relationship between non-alcoholic fatty liver disease (NAFLD) and cholelithiasis. It has been established that the high prevalence and progression rate of NAFLD, as well as cholelithiasis, depend on a number of risk factors, which are predominantly common. For example, NAFLD is 3.5 times more likely to be associated with cholelithiasis than with other diseases of the gastrointestinal tract (GIT). In turn, cholelithiasis can have serious metabolic effects predisposing to the development of NAFLD, and bile acids are now considered less as «surfactants/detergents» facilitating fat absorption, as previously thought, than as signaling molecules that coordinate the regulation of metabolism and inflammation, and not only in the GIT, but also in other organs and systems. It still remains unclear what disease develops primarily, or they are developed in parallel, but their negative impact on each other is precisely known.

About the Autors


Corresponding author: P.V. Seliverstov – PhD, Associate Professor at the Department of Internal Medicine and Nephrology, North-Western State Medical University of Mechnikov, Saint-Petersburg, Russia, e-mail: seliverstov-pv@yandex.ru, tel. +7 (812) 303-50-00, e-mail: seliverstov-pv@yandex.ru


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