ALGORITHM OF TREATMENT OF NON-ALCOHOLIC FATTY OF LIVER DISEASE AND THE ROLE OF MITOCHONDRIAL DYSFUNCTION IN ITS DEVELOPMENT


V.G. Radchenko, P.V. Seliverstov, V.F. Ivanova, S.I. Sitkin

FSBEI HE “North-Western State Medical University n.a. I.I. Mechnikov”of RMH, St. Petersburg
The lack of a unified concept of the essence of the processes occurring in non-alcoholic fatty liver disease (NAFLD), scarcity of clinical symptoms, and the limited possibilities for timely diagnosis cause the interest of physicians of various specialties in seeking solutions to this problem. The issues related to the evaluation of etiopathogenesis, diagnosis, treatment and prevention of steatosis in patients with NAFLD still remain an urgent task for the world healthcare. Symptoms of mitochondrial dysfunction, such as changes in the lipidogram and lipid peroxidation indices, as well as in the hepatic cell during electron microscopy, arising from steatosis, confirm its role in the development and progression of the disease. This fact should be taken into account when drawing up a diagnosis plan and an algorithm for treating patients with NAFLD.

About the Autors


Corresponding author: P.V. Seliverstov – PhD, Associate Professor at the Department of Internal Diseases and Nephrology FSBEI HE NWSMU n.a.
I.I. Mechnikov of RMH, St. Petersburg; tel. 8 (812) 303-50-00, e-mail: seliverstov-pv@yandex.ru


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