GLYCEMIC VARIABILITY AS A THERAPEUTIC TARGET IN THE TREATMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS


A.S. Ametov (1), N.A. Chernikova (1), T.Yu. Demidova (1), P.K. Nazhmutdinova (2)

(1) SBEI FPE "Russian Medical Academy of Postgraduate Education" of RMPH, Moscow; (2) LLC "Novartis Pharma", Moscow
To date, accumulated data suggest that the use of glycemic parameters in conjunction with the glycated hemoglobin levels and other traditional risk factors can improve the accuracy of prediction of the development of vascular complications and hypoglycemia in diabetes mellitus (DM). Assessment of glycemic variability is the most promising approach to the evaluation of the effectiveness of diabetes control, and reduction of glycemic variability can be considered as one of the important therapeutic targets in the treatment of DM [34]. As a consequence, more and more attention is paid to the evaluation of impact of various glucose-lowering drugs on the parameters of glycemic variability, in particular dipeptidyl peptidase-4 inhibitors, which have glucose-dependent effect on the function of pancreatic β- and alpha-cells.

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About the Autors


Ametov A.S. – Doctor of Medical Scineces, Professor, Head of the Department of Endocrinology and Diabetology SBEI FPE RMAPE of RMPH, Moscow; e-mail: endocrin@mtu-net.ru


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