NONALCOHOLIC FATTY LIVER DISEASE: NEW POTENTIALS FOR THE COMBINED THERAPY


S. M. Alekhin, M. N. Somova

Nonalcoholic fatty liver disease has a high prevalence in the population worldwide. In the pathogenesis of the disease, insulin resistance and oxidative stress of hepatocytes and the subsequent development of inflammatory and necrotic changes in the liver play a leading role. Treatment is aimed at weight loss, overcoming insulin resistance, prevention of oxidative stress, and normalization of intestinal biocenosis. One promising area in the treatment is the use of combined hepatoprotectors acting on the various links of pathogenesis of the disease. An example is the combination of essential phospholipids and substances with antioxidant and metabolic action - vitamin E and L-carnitine.

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