SARTANS IN THE TREATMENT OF ARTERIAL HYPERTENSION IN THE PRACTICE OF PRIMARY CARE PHYSICIAN


A.M. Shilov

SBEI HPE "First MSMU n.a. I.M. Sechenov" of RMPH, Moscow
The article presents the history of the investigation of the renin-angiotensin-aldosterone system (RAAS) and its role in the cardiovascular continuum. The major steps of the synthesis of the main mediator – angiotenzin II - and structure of RAAS with detailing the functions of the angiotensin receptor are discussed in detail. Possible places of RAAS blockade using sartans, angiotenzin receptor blockers, are discussed . The mechanisms of blockade of angiotensin receptors – AR1, and its clinical significance in the treatment of cardiovascular diseases are described in detail. Comparative characteristics of two generations of angiotensin receptor blockers are presented. The literature data on the clinical relevance and the pleiotropic effects of telmisartan, second generation bifunctional sartan, the in the treatment of cardiovascular diseases are demonstrated.

About the Autors


A.M. Shilov – MD, Prof., Head. of the Department of emergency conditions in internal diseases FPGEP SBEI HPE "First MSMU n.a. I.M. Sechenov" of RMPH; e-mail: Alexmshilov@mail.ru


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