LIPID PEROXIDATION AND ACTIVITY OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 IN THE SERUM IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE


L.A. Zvenigorodskaya, M.V. Shinkin, T.V. Nilova, A.V. Petrakov, A.E. Lychkova

SBHCI "Moscow Clinical Research and Practical Center" of the Moscow Healthcare Department
The article presents the results of evaluation of the malondialdehyde (MDA) levels in 80 patients with non-alcoholic fatty liver disease (NAFLD), the relationship of peroxidation and phospholipase mechanisms of hepatocyte membrane damage with other markers of inflammation. Basic morphological changes in examined patents were characterized by macrovesicular hepatic steatosis. The analysis of biochemical parameters showed 2-3-fold increase of aminotransferase and gamma-glutamyl levels in 40% of cases. Lipid spectrum in examined patients was characterized by an increase in total cholesterol, LDL, triglycerides and decrease in high-density lipoprotein levels. Relationship between inflammatory markers (lipoprotein-associated phospholipase A2 - LpPLA2, nitric oxide - NO, endotoxin - ET, MDA), morphological pattern of the hepatic injury and activity of liver enzymes was revealed. LpPLA2 activity in 40% of NAFLD patients was increased by 3.8 times compared with that of in the control group and in patients with steatosis, and it was accompanied by an increase in liver enzyme activity and severity of morphological changes. NAFLD leads to the development of antioxidant system failure as a result of the activation of lipid peroxidation. In patients with NAFLD, serum MDA levels were 2-fold increased, in patients with steatohepatitis – in 30% of cases. LpPLA2 activity and MDA levels had correlation (r = -578). Increase in ET, NO levels and LpPLA2 activity were observed with the progression of inflammatory liver infiltration.

About the Autors


L.A. Zvenigorodskaya – Doctor of Medical Sciences, Professor, Leading Researcher of the Endocrinological Service SBHCI "Moscow Clinical Research and Practical Center" of the Moscow Healthcare Department


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