THE USE OF MILDRONATE IN PATIENTS WITH CEREBROVASCULAR DISEASE


M.Yu. Maximova, T.N. Fedorova, T.N. Sharypova

Based on the clinical, psychological and electrophysiological examinations of patients with acute and chronic cerebrovascular disease, efficacy and favorable tolerability of treatment with Mildronate (3 - (2,2,2-trimethylhydrazinium) propionate dihydrate) is demonstrated. The drug reduces the severity of neurological disorders, improves psychological functions of patients. The biochemical basis for the therapeutic action of Mildronate includes antioxidant activity: the drug reduces oxidative damage of lipoprotein structures, restores the activity of the endogenous antioxidant system. Using single-photon emission computed tomography, it was established that Mildronate increases cerebral perfusion in areas of its decline, which are attributable to cerebral infarcts on magnetic resonance imaging.

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