Treatment Of Ulcerative Colitis: Experience Of Use Of Methotrexate In Ssc Of Coloproctology


Mihailova T.L., Makarchuk P.A., Golovenko O.V., Veselov A.V.

The article is concerned with possibilities of use of methotrexate in patients with ulcerative colitis (UC) with hormone dependence or hormone resistance. Authors present the experience of use of methotrexate in the treatment of 72 patients with severe UC. Hormone resistance was indication for administration of methotrexate in 59 patients, and hormonal dependence - in 13 patients. The drug was administered at a dose of 25 mg per week for one year against the background of gradual withdrawal of prednisolone. The overall effectiveness of methotrexate in severe UC was 63.8%. During the year, aggravation of UC was registered in 23.3% of patients against the background of maintenance therapy with methotrexate. It is emphasized that the use of methotrexate allows completely discontinuing hormone therapy in hormone-related forms of UC.

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