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Clinical Significance Of Antibiotics Modified Release Oral Formulations
M.V. Leonova, M.A. Muchina
Clinical significance of antibiotics modified release oral formulations
The authors studied clinical advantages of antibiotics modified release oral formulation, which are very important for clinical practice. Such antibiotics include azithromycin ER and clarithromycin ER. These formulations have special pharmacokinetic feature – delayed absorption in distal areas of gastrointestinal tract, what decreases the contact with motilin receptors and improves antibiotics tolerability. Because of the high tissue penetration optimal tissue concentration of such antibiotics are preserved for a long time. Modified release oral formulations allows to achieve better clinical results, increase tolerability and decrease the frequency of antibiotis dosing, that result in better patients compliance.
The authors studied clinical advantages of antibiotics modified release oral formulation, which are very important for clinical practice. Such antibiotics include azithromycin ER and clarithromycin ER. These formulations have special pharmacokinetic feature – delayed absorption in distal areas of gastrointestinal tract, what decreases the contact with motilin receptors and improves antibiotics tolerability. Because of the high tissue penetration optimal tissue concentration of such antibiotics are preserved for a long time. Modified release oral formulations allows to achieve better clinical results, increase tolerability and decrease the frequency of antibiotis dosing, that result in better patients compliance.
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