Combination therapy of a patient with chronic heart failure and type 2 diabetes mellitus: a clinical case of meldonium use


DOI: https://dx.doi.org/10.18565/pharmateca.2025.2.151-156

M.E. Statsenko, S.V. Fabritskaya, M.V. Derevyanchenko

Volgograd State Medical University, Volgograd, Russia
Background: About 26 million people in the world suffer from chronic heart failure (CHF). Along with the main causes of CHF (coronary artery disease (CAD), arterial hypertension – AH), diabetes mellitus (DM) also occupies a leading position. The combination of CHF and DM determines a more unfavorable prognosis and encourages the search for ways to optimize the therapy of such comorbid patients.
Description of the clinical case: A clinical example of the use of combination therapy with the inclusion of meldonium in a patient with CHF with preserved EF and type 2 DM is presented. Against the background of treatment optimization, at the end of the 6th week of follow-up, regression of the severity of CHF symptoms, a decrease in the number of ventricular extrasystoles, and an improvement in the quality of life were noted.
Conclusion: The use of meldonium can be recommended to enhance basic therapy in patients with CHF with preserved EF in conditions of comorbidity (coronary artery disease, type 2 diabetes).
Keywords: meldonium, comorbidity, clinical case, diabetes mellitus, chronic heart failure
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About the Autors

Mikhail E. Statsenko, Dr. Sci. (Med.), Professor, Head of the Department of Internal Medicine, Volgograd State Medical University, Volgograd, Russia; mestatsenko@rambler.ru, ORCID: https://orcid.org/0000-0002-3306-0312 (corresponding author)
Svetlana V. Fabritskaya, Cand. Sci. (Med.), Associate Professor of the Department of Internal Medicine, Volgograd State Medical University, Volgograd, Russia; lanabelenkova@mail.ru, ORCID: https://orcid.org/0000-0002-5736-2235
Mariya V. Derevyanchenko, Dr. Sci. (Med.), Professor of the Department of Internal Medicine, Volgograd State Medical University, Volgograd, Russia; derevjanchenko@gmail.com, ORCID: https://orcid.org/0000-0002-6232-4583


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