Obesity and atrial fibrillation: new treatment options


DOI: https://dx.doi.org/10.18565/pharmateca.2025.1.270-275

A.I. Tarzimanova, V.F. Valitova, K.O. Speranskaya, E.Sh. Samedova, A.A. Okhtova

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
The prevalence of obesity and atrial fibrillation (AF), which are inextricably linked, is rapidly growing worldwide. A number of clinical studies have shown that weight loss significantly reduces the risk of arrhythmia and its natural progression. Along with weight loss, the tactics of managing patients with obesity and AF include risk factor correction, anticoagulant therapy for increased risk of thromboembolic complications, and control of arrhythmia symptoms. One of the significant difficulties in treating patients with obesity and AF is the administration of a large dose of an antiarrhythmic drug to stop and prevent paroxysms of arrhythmia. In obese patients, there is a change in the volume of distribution and excretion of drugs, which in turn affects the half-life of the drug. Correction of cardiovascular risk factors in obese patients with AF includes therapy aimed at reducing the activity of the renin-angiotensin-aldosterone system, and treating carbohydrate and lipid metabolism disorders.
Keywords: weight correction, antiarrhythmic therapy, obesity, atrial fibrillation
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About the Autors

Aida I. Tarzimanova, Dr. Sci. (Med.), Professor, Department of Faculty Therapy No. 2, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; tarzimanova@mail.ru, ORCID: https://orcid.org/0000-0001-9536-8307 (corresponding author)
Valeria F. Valitova, Resident, Department of Faculty Therapy No. 2, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; ORCID: https://orcid.org/0009-0009-0729-7760
Ksenia O. Speranskaya, Student, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; ORCID: https://orcid.org/0009-0001-9793-4963
Esmira Sh. Samedova, Student, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; ORCID: https://orcid.org/0009-0008-8458-3739
Asiyat A. Okhtova, student, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; ORCID: https://orcid.org/0009-0006-1818-9480


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