Background. Despite the significant decline in the prevalence of COVID-19 around the world, the consequences of the pandemic on the health and quality of life of patients according to the data from clinical studies will remain a leading public health issue for a long time.
Objective. Dynamic evaluation and analysis of the N-terminal pro C-type natriuretic peptide (NUPC) and endothelin-1 (ET-1) levels in patients six months after COVID-19 against the background of arterial hypertension (AH), depending on the stratification of cardiovascular risk in AH.
Methods. 45 hypertensive patients with confirmed diagnosis of coronavirus infection COVID-19 (virus identified) who were treated in an infectious diseases hospital were examined. Determination of the NUPC and ET-1 levels in blood serum samples was carried out using the enzyme immunoassay method. Biomarker levels were determined twice – on the first day of admission to the hospital and six months after discharge. Cardiovascular risk in AH was also assessed twice – on the first day of admission to the hospital and six months after discharge.
Results. Analysis of the NUPC and ET-1 levels on hospital admission between patients with moderate risk (risk 2) and high risk (risk 3) did not show statistically significant differences (P=0.487, P=0.821, respectively). Six months after COVID-19, in hypertensive patients with very high risk (risk 4), the levels of both ET-1 and NUPC were statistically significantly higher than in patients with high risk (risk 3) (P=0.012 and P<0.001, respectively). An increase in cardiovascular risk in AH six months after discharge from hospital was observed in 15 (33.3%) patients, and in 30 (66.7%) patients, cardiovascular risk in AH remained the same. In hypertensive patients who experienced an increase in cardiovascular risk six months after discharge from hospital for COVID-19, the levels of both ET-1 and NUPC were statistically significantly higher compared with patients who cardiovascular risk in AH did not change (P=0.01 and P<0.001, respectively).
Conclusion. According to the results of the study, it was found that the highest levels of both ET-1 and NUPC six months after discharge from the hospital were in patients with a very high risk (risk 4) and in patients who had an increase in cardiovascular risk in AH.

Keywords: N-terminal precursor of type C natriuretic peptide, cardiovascular risk, endothelin-1, arterial hypertension