Correction of cognitive impairment associated with age-dependent cerebral microangiopathy after COVID-19 using the combination drug vinpocetine+piracetam: clinical case report


Vorob’eva O.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow
Cerebral microangiopathy may progress slowly and begin to manifest massive cognitive impairment when a certain brain damage threshold is reached, or more dramatically when inciting events such as infection with the SARS-CoV2 virus occur. Evidence-based therapeutic interventions for post-COVID-19 cognitive impairment have not yet been developed, and clinicians must rely on their own assumptions to help patients. Due to the anti-inflammatory mechanism of action and effectiveness in the treatment of cognitive impairment, as well as good tolerability, the combination drug vinpocetine+piracetam was proposed as a means of correcting cognitive symptoms after COVID-19. The effect of this drug on cognitive function and systemic inflammation, tested by inflammatory markers, was demonstrated in the presented clinical case report.

About the Autors

Corresponding author: Olga V. Vorobyova, Dr. Sci. (Med.), Professor at the Department of Nervous Diseases, Institute of Professional Education, 
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;; ORCID:

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