Clinical features of ulcerative colitis and Crohn’s disease in St. Petersburg: experience of the city inflammatory bowel disease center


Uspenskiy Yu.P., Petrov S.V., Fominykh Yu.A., Ivanov S.V., Lykova E.P.

1) St. Petersburg State Pediatric Medical University, St. Petersburg, Russia; 2) Elizavetinskaya Hospital, St. Petersburg, Russia; 3) Almazov National Medical Research Center, St. Petersburg, Russia
Background. Inflammatory bowel diseases (IBDs) are a pressing problem in gastroenterology around the world due to a recurrent course, a pronounced decrease in quality of life, disabling complications and the difficulties of individual selection of therapy.
Objective. Clinical assessment of the course and treatment of IBD in a cohort of patients who were followed-up to the City IBD Center in Elizavetinskaya Hospital, St. Petersburg.
Methods. A cross-sectional sample study that included demographic and clinical data of 516 patients with IBD who visited a City IBD Center in 2020–2023 was conducted. This sample of patients was compared with a cohort of 1078 patients with IBD who received treatment in 42 clinics and 6 hospitals in St. Petersburg in 2018–2020.
Results. Systematic differences between the cohort of patients who received treatment in the City IBD Center and the cohort of patients with this pathology who received drug treatment in medical institutions in the city healthcare system were identified. In the City IBD Center, patients with complicated, moderate and severe course of the disease were mainly followed-up. In the structure of extraintestinal manifestations, peripheral arthropathy and damage to the mucous membranes were in the lead, and in the structure of identified complications – anemia and protein-energy deficiency. Distinctive features of drug therapy prescribed for the management of patients at the IBD Center were the widespread use of genetically engineered biological therapy, as well as the active use of immunosuppressants in the treatment of Crohn’s disease, which is fully consistent with current clinical recommendations. Conclusion. In the City IBD Centers within the framework of the St. Petersburg City Healthcare System, the most clinically difficult patients with ulcerative colitis and Crohn’s disease are followed-up and receive the necessary treatment. The importance of City IBD Centers in providing specialized gastroenterological care to patients of this category in St. Petersburg will increase in the coming years.

About the Autors

Corresponding author: Sergey V. Ivanov, Cand. Sci. (Med.), Associate Professor at the Department of Faculty Therapy n.a. prof. V.A. Valdman, 
St. Petersburg State Pediatric Medical University; Associate Professor at the Department of Propaedeutics of Internal Diseases with a Clinic, Almazov National Medical Research Center, St. Petersburg, Russia;

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