Metabolic processes in the liver are closely related to the work of the thyroid gland. In this regard, it is necessary to exclude the pathology of the thyroid gland with an increase in the transaminase level for an unknown reason. It is known that diffuse toxic goiter is the leading cause of thyrotoxicosis. In patients with newly diagnosed hyperthyroidism, biochemical abnormalities in the blood test, indicating liver dysfunction, are recorded quite often, while clinical manifestations, as a rule, may not be expressed. The article discusses the issues of diagnosing hepatopathy in patients with thyrotoxicosis, the need to differentiate true thyrotoxic damage from concomitant liver diseases of a viral and autoimmune nature, drug-induced liver damage. The authors present a clinical case of acute toxic hepatitis caused by thiamazole in a patient with diffuse toxic goiter.

Keywords: toxic goiter, thyreostatic therapy, Graves’ disease, hepatitis, cholestasis, thyrotoxicosis