Rare clinical variant of palmoplantar keratoderma

DOI: https://dx.doi.org/10.18565/pharmateca.2023.8.126-128

Yu.A. Novikov, O.V. Pravdina, E.A. Zykova, S.R. Gamza

1) Omsk State Medical University, Department of Dermatovenereology and Cosmetology, Omsk, Russia; 2) Clinical Dermatovenerologic Dispensary, Omsk, Russia
The article presents a clinical case of an 18-year-old patient with aquagenic keratoderma. This is a rare variant of acquired palmoplantar keratoderma, which is characterized by the appearance of dense waxy foci of white-yellow hyperkeratosis with swelling of the skin, lichenification, as well as plaques with a surface in the form of a «cobblestone pavement» after contact with water. Aquagenic keratoderma occurs in 44–80% of cases in patients with cystic fibrosis who have a homo- or heterozygous mutation δF508 in the CFTR gene responsible for regulating electrolyte transport. This clinical case is of interest to practicing dermatologists.

About the Autors

Corresponding author: Elena A. Zykova, Cand. Sci. (Med.), Teaching Assistant, Department of Dermatovenereology and Cosmetology, Omsk State Medical University, Omsk, Russia; zyk.alena@mail.ru

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