Background. A comparative assessment of the effect of therapy with angiotensin-converting enzyme inhibitors (lisinopril, fosinopril or zofenopril) on the structural and functional parameters of the heart and subjective parameters of quality of life (QoL) in patients with essential hypertension (AH) was carried out.
Methods. The study included 120 patients randomly divided into three groups. Patients with arterial hypertension and functional class I and II chronic heart failure with preserved left ventricular ejection fraction underwent echocardiography, 24-hour blood pressure monitoring, treadmill test, 6-minute walk test, determination of the blood plasma N-terminal precursor brain natriuretic peptide level, calculation of glomerular filtration rate, and subjective assessment of QoL using the Minnesota questionnaireat the beginning of therapy and after 24 weeks.
Results. Lisinopril, fosinopril and zofenopril showed comparable sufficient organoprotective, antihypertensive and neuromodulatory activity in hypertensive patients. Significant differences in influence ofthese drugs on exercise tolerance and subjective parameters of patients’ QoL were revealed.
Conclusion. Fosinopril, compared with lisinopril, increased exercise tolerance to a greater extent, improved the subjective parameters of QoL. Fosinopril increased exercise tolerance to a greater extent than zofenopril. Compared to lisinopril, zofenopril improved the subjective parameters of QoL to a greater extent.

Keywords: zofenopril, fosinopril, lisinopril, hypertension, quality of life