On the question of the use of isotretinoin forms with various bioavailability for the treatment of severe acne

DOI: https://dx.doi.org/10.18565/pharmateca.2022.8.48-57

O.A. Bitkina, P.L. Krivonogova, I.V. Kosheleva, A.K. Martusevich, T.V. Kopytova, A.A. Tsyganova, Abdullahi Mohamed Bashir

1) Privolzhsky Research Medical University, Department of Skin and Venereal Diseases, Nizhny Novgorod, Russia; 2) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 3) Privolzhsky Research Medical University, Laboratory of Medical Biophysics, University Clinic, Nizhny Novgorod, Russia; 4) Privolzhsky Research Medical University, Department of Biochemistry n.a. G.Ya. Gorodisskaya, Nizhny Novgorod, Russia
Using the methods of classical crystalloscopy and comparative tesigraphy, a violation of protein homeostasis in patients with severe acne was established, and based on the biochemical and biocrystallomic tests, the effect of various forms of isotretinoin on was shown. It has been shown that, therapy with isotretinoin with a higher bioavailability with a comparable clinical effect has a less pronounced negative effect on body homeostasis, and the constitutional characteristics of the albumin molecule, the main indicator of the level of oxidative stress, are restored during therapy. It has also been shown that changes in the blood serum crystallogenic activity, as well as constitutional changes in the albumin molecule of patients with acne are one of the important factors in the pathogenesis of the disease. The method of assessing the blood serum crystallogenic activity, assessing the effective albumin level in patients with acne can be used as a criterion for the effectiveness of therapy with systemic isotretinoin.

About the Autors

Corresponding author: Oksana A. Bitkina, Dr. Sci. (Med.), Professor, Department of Skin and Venereal Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia; oksana381@yandex.ru

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