Background. Primary adrenal insufficiency (PAI) is a disease characterized by decreased production of adrenal hormones. As a rule, this term refers to various variants of hypocorticism vary in etiology and pathogenesis. In childhood, in terms of genesis, hereditary syndromes prevail, in which adrenal insufficiency (AI) with a gradual onset and slow progression is diagnosed. Gastrointestinal disorders – loss of appetite, nausea, vomiting – are sometimes observed already at the onset of the disease and necessarily occur with an augmentation of AI.
Description of the clinical case. The article deals with a clinical case of PAI in a child of 11 years old, which manifested itself against the background of a novel coronovirus infection COVID-19.
Conclusion. Most symptoms of cortisol and aldosterone deficiency are nonspecific and may be a sign of diseases of other organs and systems (gastrointestinal tract, central nervous system, etc.). Diagnostic search for a specific nosological form of AI allows predicting the course of the disease, the likelihood of the appearance of pathology in other organs and systems, and determining the tactics of management of the patient.

Keywords: Gitelman syndrome, X-linked adrenoleukodystrophy, hypocorticism, COVID-19, hyponatremia, adrenal insufficiency