Русский
Patterns of changes in the cellular composition of the gastric glands in chronic gastritis in children and adolescents
DOI: https://dx.doi.org/10.18565/pharmateca.2022.1.62-66
E.M. Spivak (1), A.I. Khavkin (2, 3)
1) Yaroslavl State Medical University, Yaroslavl, Russia; 2) Research Clinical Institute of Childhood, Moscow, Russia; 3) Belgorod State Research University, Belgorod, Russia
Background. The development of a strategy for treatment of children with chronic gastritis is impossible without its confirmation in the morphological study of biopsy specimens of the gastric mucosa.
Objective. Determination of the patterns of changes in the cellular composition
Methods. 213 patients aged 7–17 years with chronic Hp-associated gastritis were examined. In gastrobiopsy specimens, the cellular composition of the fundic and pyloric glands was determined. Cells containing gastrin, somatostatin, pepsinogens I and II, acidic and neutral mucins were determined using immunohistochemistry assay. The results were expressed in ‰ per 1000 epitheliocytes.
Results. As inflammation increases in the fundic glands, the number of chief cells and cells containing pepsinogens I and II decreases, and the number of parietal, mucoid, and endocrine cells increases. In the pyloric glands, the pool of endocrinocytes increases, and the number of parietal cells and cells immunopositive to pepsinogen II decreases significantly. In parallel with the severity of the process, a sharp increase in D- and G-cells is observed, and the number of epitheliocytes containing acidic and neutral mucins increases.
Conclusion. Chronic inflammation of the gastric mucosa is accompanied by a significant restructuring of the cellular composition of its glands.
Objective. Determination of the patterns of changes in the cellular composition
Methods. 213 patients aged 7–17 years with chronic Hp-associated gastritis were examined. In gastrobiopsy specimens, the cellular composition of the fundic and pyloric glands was determined. Cells containing gastrin, somatostatin, pepsinogens I and II, acidic and neutral mucins were determined using immunohistochemistry assay. The results were expressed in ‰ per 1000 epitheliocytes.
Results. As inflammation increases in the fundic glands, the number of chief cells and cells containing pepsinogens I and II decreases, and the number of parietal, mucoid, and endocrine cells increases. In the pyloric glands, the pool of endocrinocytes increases, and the number of parietal cells and cells immunopositive to pepsinogen II decreases significantly. In parallel with the severity of the process, a sharp increase in D- and G-cells is observed, and the number of epitheliocytes containing acidic and neutral mucins increases.
Conclusion. Chronic inflammation of the gastric mucosa is accompanied by a significant restructuring of the cellular composition of its glands.
About the Autors
Corresponding author: Evgeny M. Spivak, Dr.Sci. (Med.), Professor, Department of Pediatrics № 1, Yaroslavl State Medical University, Yaroslavl, Russia; spivak58@mail.ru
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