β-cell dysfunction in type 2 diabetes mellitus: the possibilities of modern antihyperglycemic therapy


DOI: https://dx.doi.org/10.18565/pharmateca.2021.12.60-65

N.A. Chernikova

Department of Endocrinology, Russian Medical Academy of Continuous Professional Education, Moscow, Russia
This review reveals the current understanding of the role of β-cell dysfunction in the onset and development of type 2 diabetes mellitus (T2DM). The pathological processes underlying the impaired insulin secretion in T2DM are described. The data on the influence of mo-dern antihyperglycemic therapy on the functional state of β-cells are presented.
Keywords: incretin mimetics, early insulin therapy, β-cells, type 2 diabetes mellitus
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About the Autors

Corresponding author: Natalia A. Chernikova, Cand. Sci. (Med.), Associate Professor at the Department of Endocrinology, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; ORCID: https://orcid.org/0000-0002-0562-8396


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