Risk factors of drug-induced diseases. Part 1. Classification, non-modified risk factors

DOI: https://dx.doi.org/10.18565/pharmateca.2021.11.34-46

D.A. Sychev (1), O.D. Ostroumova (1), M.S. Chernyaeva (2), A.P. Pereverzev (1), A.I. Kochetkov (1), T.M. Ostroumova (3), M.V. Klepikova (1), E.Yu. Ebzeeva (1), V.A. De (1)

1) Russian Medical Academy of Continuing Professional Education, Moscow, Russia; 2) Central State Medical Academy, Moscow, Russia; 3) I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Drug-induced diseases (DIDs) have a high prevalence in the population, cause symptoms that force them to seek medical attention or lead to hospitalization, including in the intensive care unit, and a number of DIDs can increase mortality. Some patients are more predisposed to the development of DIDs due to the presence of a number of risk factors. Risk factors for DIDs are divided into general, specific for a particular drug or class of drugs, as well as specific risk factors that increase the risk of developing a particular DIDs. Common risk factors include non-modifiable, partially modifiable and modifiable risk factors. This article describes in detail the most important unmodifiable risk factors, the presence of which increases the likelihood of developing DIDs, as well as examples of their clinical consequences and methods of prevention. Non-modifiable risk factors include: old age, female gender, race, pregnancy, and genetic traits. For effective prevention of the development of DIDs, it is important to assess the presence of risk factors for their development in the patient before taking medications. If unmodifiable risk factors are identified, it is necessary to use all known measures to prevent the development of a potentially possible DIDs, conduct patient education, in addition, careful monitoring of the patient’s condition is very important for the timely detection of a potential DIDs during therapy.

About the Autors

Corresponding author: Marina S. Chernyaeva, Cand. Sci. (Med.), Associate Professor of the Department of Internal Medicine and Preventive Medicine, Central State Medical Academy, Moscow, Russia; doctor@cherniaeva.ru
Address: build. 1A, 19 Marshal Timoshenko st., Moscow 121359, Russian Federation

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