A modern view of the development and approaches to the treatment of atopic dermatitis in children


DOI: https://dx.doi.org/10.18565/pharmateca.2020.1.20-27

I.I. Balabolkin (1), V.A. Bulgakova (1–3), T.I. Eliseeva (4)

1) National Medical Research Center for Children’s Health, Moscow, Russia; 2) Pirogov Russian National Research Medical University, Moscow, Russia; 3) Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 4) Privolzhsky Research Medical University, Nizhny Novgorod, Russia
A review presents a modern view of the development and approaches to therapy for atopic dermatitis (AtD) in children based on literature review and authors’ own research. The important role of atopy, mutations in the filaggrin gene, activation of Th2 lymphocytes, innate lymphoid cells (ILC), dendritic cells, mast cells, basophils, eosinophils, Langerhans cells, keratinocytes, Th1 cells, Treg, increased production of immunoglobulin E (IgE), mediators, chemokines and cytokines (IL-4, IL-5, IL-8, IL-9, IL-13, IL-17, IL-25, IL-31, interferon γ and tumor necrosis factor α), impaired skin barrier function in the pathogenesis of AtD is demonstrated. The clinical and immunological characteristics of IgE-mediated and non-IgE-mediated AtD are presented. The therapeutic efficacy of pathogenetic therapy for AtD using topical glucocorticosteroids, calcineurin inhibitors, emollients, antihistamines, anti-IgE therapy and allergen-specific immunotherapy has been shown.

About the Autors


Corresponding author: Vilya A. Bulgakova, Doctor of Medical Sciences, Chief Researcher, National Medical Research Center for Children’s Health, Moscow, Russia; tel. +7 (945) 967-14-20 (ext. 1467); e-mail: irvilbulgak@mail.ru
Address: 2, build. 1, Lomonosovsky Prospect, Moscow 119991, Russian Federation


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