Русский
Determination of molecular genetic biomarkers – the way to increase the effectiveness of treatment and improving the prevention of atopic dermatitis exacerbations
DOI: https://dx.doi.org/10.18565/pharmateca.2024.10.42-48
Shadyzheva L.I., Kosheleva I.V., Nemtsova M.V.
1) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
The article presents data from a molecular-genetic study on the polymorphism of detoxifying enzyme genes glutathione S-transferases GSTM1, GSTT1, and GSTP1 in patients with atopic dermatitis.
Phenotypic features in patients with atopic dermatitis were identified depending on the genotypes of GSTT1, GSTM1, and GSTP1; it was shown that the genotypes GSTT0/0, GSTM0/0, and GSTPVal/Val or their combinations are significantly more common in patients with an early onset of the disease, with a complicated family history, with a complicated allergic history, and with a tendency for the skin process to have frequent exacerbations. It was established that in majority of patients with atopic dermatitis (31 out of 52 examined patients, or 59.6%), the combinations of genotypes GSTT0/0+GSTM0/0 and GSTPIle/Val or GSTPVal/Val are significantly more often is prognostic factor for the tendency of frequent exacerbations of the skin process.
The detection of null and inactive genotypes GSTM1, GSTT1, and GSTP1 in patients with atopic dermatitis indicates the feasibility of prescribing active personalized preventive measures to limit contact with specific exogenous xenobiotics and including enterosorbents in the comprehensive treatment.
Phenotypic features in patients with atopic dermatitis were identified depending on the genotypes of GSTT1, GSTM1, and GSTP1; it was shown that the genotypes GSTT0/0, GSTM0/0, and GSTPVal/Val or their combinations are significantly more common in patients with an early onset of the disease, with a complicated family history, with a complicated allergic history, and with a tendency for the skin process to have frequent exacerbations. It was established that in majority of patients with atopic dermatitis (31 out of 52 examined patients, or 59.6%), the combinations of genotypes GSTT0/0+GSTM0/0 and GSTPIle/Val or GSTPVal/Val are significantly more often is prognostic factor for the tendency of frequent exacerbations of the skin process.
The detection of null and inactive genotypes GSTM1, GSTT1, and GSTP1 in patients with atopic dermatitis indicates the feasibility of prescribing active personalized preventive measures to limit contact with specific exogenous xenobiotics and including enterosorbents in the comprehensive treatment.
Keywords: prevention of exacerbations of the atopic dermatitis, GSTP, GSTT, GSTM, glutathione S-transferase, atopic dermatitis
About the Autors
Corresponding author: Leyla I. Shadyzheva, Associate Professor of the Department of Dermatoveneorology and Cosmetology, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; leyla.shadyzheva@gmail.com
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