Evaluation of the kinetics of the release of active substance in the oral cavity after the use of orodispersible tablets against sore throat


DOI: https://dx.doi.org/10.18565/pharmateca.2019.1.65-69

V.V. Smirnov (1, 2), E.A. Egorenkov (2)

1) Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of Russian Federation, Moscow, Russia; 2) National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia, Moscow, Russia

Background. The incidence of acute respiratory viral infections (ARVI) in Russia is seasonal, and the morbidity is of great importance in all age and social groups. ARVI is manifested by a variety of symptoms, with sore throat as the most common. There are many different drugs used for the treatment of sore throat, but orodispersible tablets are the most popular. Material and methods. To compare the effectiveness of orodispersible tablets of different compositions and manufacturers, a method for estimating the maintenance of the active substance concentration due to its uniform release during resorption using an experimental model has been proposed. Results. As a result of a comparative analysis of various orodispersible tablets against sore throat, profiles of release and maintenance of concentration of active substances in the oral cavity are presented, as well as conclusions about the stability of release of active substance of orodispersible tablets of various productions. Conclusion. According to the results of the study, Tantum Verde (benzydamine hydrochloride) has the minimum value of the coefficient of variation for active substance release among the most popular commercial samples of orodispersible tablets presented on the territory of the Russian Federation.


For citations: Smirnov V.V., Egorenkov E.A. Evaluation of the kinetics of the release of active substance in the oral cavity after the use of orodispersible tablets against sore throat. Farmateka. 2019;26(1):65–69. (in Russian). DOI: https://dx.doi.org/10.18565/pharmateca.2019.1.65-69 


About the Autors


Corresponding author: Valery V. Smirnov, PhD in Pharmacological Sciences, Leading Research Associate at the Department of Clinical Pharmacokinetic of the Center of Clinical Pharmacology FSBI “Scientific Centre for Expert Evaluation of Medicinal Products” of the Ministry of Health of Russian Federation, Head of Laboratory of Clinical Pharmacology № 73, National Research Center «Institute of Immunology» of the Federal Medical-Biological Agency of Russia, Moscow, Russia; e-mail: vall@mail.mipt.ru; ORCID: https://orcid.org/0000-0002-8232-6682; Scopus Author ID: https://www.scopus.com/authid/detail.uri?authorId=57201338559; Address: 24, Kashirskoye Highway, Moscow 115478, Russian Federation


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