CHANGES IN ARTERIAL STIFFNESS AND ENDOTHELIAL DYSFUNCTION ON THE BACKGROUND OF ANTICOAGULANT THERAPY AFTER CARDIOEMBOLIC STROKE IN PATIENTS WITH ATRIAL FIBRILLATION


I.A. Zolotovskaya, I.L. Davydkin

FSBEI HE “Samara State Medical University” of RMH, Samara
The present study is devoted to the evaluation of the effect of anticoagulant therapy with apixaban on the parameters of arterial stiffness and endothelial dysfunction (ED) in patients with atrial fibrillation (AF) who have experienced cardioembolic stroke (CES). The study included patients with a persistent or paroxysmal form of non-valvular AF who have experienced stroke and were discharged from Samara’s vascular centers for follow-up. Patients were divided into 2 groups: 56 patients (Group 1) has received apixaban in a daily dose of 5 mg according to the recommendations. The comparison group (Group 2) included 57 patients who did not follow the recommendations for taking anticoagulants. The duration of follow-up was 182.5±5.5 days. All the examinations were carried out during the period of sinus rhythm in patients: volume sphygmography, echocardiography and tissue dopplerography, analysis of ED (von Willebrand factor, tissue plasminogen activator-1 inhibitor, antithrombin III) .The results obtained indicate that arterial stiffness and endothelial function in patients with AF who have experienced CES have a positive tendency to improve against the background of anticoagulant therapy with apixaban.

About the Autors


Corresponding author: I.A. Zolotovskaya – PhD, Teaching Assistant at the Department of Hospital Therapy with courses of Policlinic Therapy and Transfusiology SBEI HE SamSMU of RMH, Samara; e-mail: zolotovskay@list.ru


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