MODERN POSSIBILITIES OF PREVENTION AND TREATMENT OF CHOLELITHIASIS DURING PREGNANCY


Yu.B. Uspenskaya

SBEI HPE First MSMU n.a. I.M. Sechenov of RMPH, Moscow
The article presents current literature data on the epidemiology, pathogenesis and approaches to the treatment cholelithiasis and biliary sludge during pregnancy. The results of authors’ own observations allowing to identify risk factors for cholelithiasis in pregnant women are discussed. Despite transient nature of cholelithiasis and biliary sludge and spontaneous regression postpartum in part of patients, those cases in which calculi and in biliary tract microlites persist and cause complications requiring further surgery should be taking into account. The effectiveness and safety of ursodeoxycholic acid in combination with cholekinetics/choleretics in the treatment and prevention of biliary sludge in pregnant women are demonstrated. In the presence of biliary sludge, dynamic monitoring of the gallbladder functions during pregnancy and the postpartum period, especially in high-risk groups, and, if necessary, carrying out a long-term and/or repeated courses of treatment are feasible.

About the Autors


Corresponding author: Yu.B. Uspenskaya – PhD, Leading Researcher at the Scientific Research Department of Women’s Health SRC SBEI HPE First MSMU n.a. I.M. Sechenov of RMPH, Moscow; e-mal: jusp@mail.ru


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