APPLICATION OF SAXAGLIPTIN AND ITS COMBINATION WITH METFORMIN IN THE THERAPY OF TYPE 2 DIABETES MELLITUS IN ELDERLY PATIENTS


M.B. Antsiferov

SBHCI Endocrinological Dispensary of Moscow Healthcare Department
The article discusses the features of the course of diabetes mellitus (DM) in elderly patients, hypoglycemic therapy in which has its own characteristics. The use of antidiabetic drugs with a minimum dose frequency during the day and a low risk of side effects - nephrotoxicity, hepatotoxicity and hypoglycemia - is an important principle of treatment of such patients. Prospects of use of dipeptidyl peptidase-4 inhibitor saxagliptin in elderly patients with type 2 diabetes are considered. Currently, there are 6 international, placebo-controlled studies of efficacy and safety of this drug in DM2 patients over age 65 years. Their results suggest that the therapy with saxagliptin and combination of saxagliptin + metformin in elderly DM2 patients is is sufficiently safe and effective in relation to the risk of hypoglycaemia and cardiovascular events.

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  21. Epub ahead of print


About the Autors


M.B. Antsiferov – Doctor of Medical Scineces, Professor, Chief Physician SBHCI "Endocrinological Dispensary" of Moscow Healthcare Department; tel. 8 (499) 246-61-75


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