O.A.Gromova (1), A.V. Pronin (1), I.Yu.Torshin (2), D.P. Kalinsky, T.R. Grishina (1), A.N.Gromov (3)

(1) SBEI HPE "Ivanovo State Medical Academy" of RMPH, Ivanovo; (2) FSAEI HPE "Moscow Institute of Physics and Technology", Dolgoprudny; (3) SBEI HPE "Pacific State Medical University" of RMPH, Vladivostok
The article systematizes vitamin D effects on the nervous system. The results of numerous studies showed the need for vitamin D in order to maintain homeostasis of neurotransmitters, hippocampus functioning, the development and functioning of the cerebral cortex. Clinical studies have shown that adequate supply of vitamin D supports sustainable psycho-emotional background, cognitive ability, memory, fine motor skills, fluency - essential components of successful learning.


1. Ребров В.Г., Громова О.А. Витамины, макро- и микроэлементы. М., 2008, 986 с.

2. Торшин И.Ю., Громова О.А. 25 мгновений молекулярной фармакологии. М., 2012. 684 с.

3. Houston D.K. Vitamin D and Age-Related Health Outcomes: Movement, Mood, and Memory. Curr. Nutr. Rep. 2015;4(2):185–200.

4. Громова О.А., Торшин И.Ю. Витамин D. Смена парадигмы / Под ред. Е.И. Гусева, И.Н. Захаровой. М., 2015. 464 с.

5. Holick M.F. Vitamin D status: measurement, interpretation, and clinical application. Ann. Epidemiol. 2009;19(2):73–8.

6. Kumar J., Muntner P., Kaskel F.J., Hailpern S.M. MLM Prevalence and associations of 25-hydroxyvitamind D deficiency in US children: NHANES 2001–2004. Pediatrics. 2009;124:362–70.

7. Захарова И.Н., Мальцев С.В., Боровик Г.В., Яцык Т.Э., Малявская С.И., Вахлова И.В., Шуматова Т.А., Романцова Е.Б., Романюк Ф.П., Климов Л.Я., Елкина Т.Н., Пирожкова Н.И., Колесникова С.М., Курьянинова В.А., Васильева С.В., Мозжухина М.В., Евсеева Е.А. Результаты многоцентрового исследования «РОДНИЧОК» по изучению недостаточности витамина D у детей раннего возраста в России. Педиатрия. Журнал им. Г.Н. Сперанского. 2015;1:62–70.

8. Торшин И.Ю., Громова О.А., Лиманова О.А., Сардарян И.С., Малявская С.И., Гришина Т.Р., Галустян А.Н., Волков А.Ю., Калачева А.Г., Громов А.Н., Рудаков К.В. Обеспеченность витамином D детей и подростков 7–14 лет и взаимосвязь дефицита витамина D с нарушениями здоровья детей. Анализ крупномасштабной выборки пациентов посредством интеллектуального анализа данных. Педиатрия. Журнал им. Г.Н. Сперанского. 201;94(2):175–84.

9. McCann J.C., Ames B.N. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 2008;22(4):982–1001.

10. Schlogl M., Holick M.F. Vitamin D and neurocognitive function. Clin. Interv. Aging. 2014;9:559–68.

11. Kesby J.P., Eyles D.W., Burne T.H., McGrath J.J. The effects of vitamin D on brain development and adult brain function. Mol. Cell. Endocrinol. 2011;347(1–2):121–7.

12. Fiorito L.M., Marini M., Mitchell D.C., Smiciklas-Wright H., Birch L.L. Girls’ early sweetened carbonated beverage intake predicts different patterns of beverage and nutrient intake across childhood and adolescence. J. Am. Diet. Assoc. 2010;110(4):543–50.

13. Громова О.А., Торшин И.Ю., Пронин А.В., Гоголева И.В., Майорова Л.А. Нейростероидные эффекты витамина D. роль в педиатрии. Фарматека. 2015;11:78–87.

14. Stachowiak M.K., Goc A., Hong J.S., Poisner A., Jiang H.K., Stachowiak E.K. Regulation of tyrosine hydroxylase gene expression in depolarized non-transformed bovine adrenal medullary cells: second messenger systems and promoter mechanisms. Brain. Res. Mol. Brain. Res. 1994;22(1–4):309–19.

15. Dicou E. Neurotrophins and neuronal migration in the developing rodent brain. Brain. Res. Rev. 2009;60(2):40–17.

16. Kholodilov N.1., Yarygina O., Oo T.F., Zhang H., Sulzer D., Dauer W., Burke R.E. Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets. J. Neurosci. 2004;24(12):3136–46.

17. Borges M.C., Martini L.A., Rogero M.M. Current perspectives on vitamin D, immune system, and chronic diseases. Nutrition. 2011;27(4):399–404.

18. Taniura H., Ito M., Sanada N., Kuramoto N., Ohno Y., Nakamichi N., Yoneda Y. Chronic vitamin D3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons. J. Neurosci. Res. 2006;83(7):1179–89.

19. McGrath J.J., Burne T.H., Feron F., Mackay-Sim A., Eyles D.W. Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update. Schizophr. Bull. 2010;36(6):1073–78.

20. McGrath J.J., Feron F.P., Burne T.H., MackaySim A., Eyles D.W. Vitamin D3-implications for brain development. J. Steroid. Biochem. Mol. Biol. 2004;89–90(1–5):557–60.

21. May H.T., Bair T.L., Lappe D.L., Anderson J.L., Horne B.D., Carlquist J.F., Muhlestein J.B. Association of vitamin D levels with incident depression among a general cardiovascular population. Am. Heart. J. 2010;159(6):1037–43.

22. Ibi M., Sawada H., Nakanishi M., Kume T., Katsuki H., Kaneko S., Shimohama S., Akaike A. Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology. 2001;40(6):761–71.

23. Shinpo K., Kikuchi S., Sasaki H., Moriwaka F., Tashiro K. Effect of 1,25-dihydroxyvitamin D(3) on cultured mesencephalic dopaminergic neurons to the combined toxicity caused by L-buthionine sulfoximine and 1-methyl-4-phenylpyridine. J. Neurosci. Res. 2000;62(3):374–82.

24. Cass W.A., Smith M.P., Peters L.E. Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Ann. N.Y. Acad. Sci. 2006;1074:261–71.

25. Brion F., Dupuis Y. Calcium and monoamine regulation: role of vitamin D nutrition. Can. J. Physiol. Pharmacol. 1980;58(12):1431–34.

26. Jang W., Kim H.J., Li H., Jo K.D., Lee M.K., Song S.H., Yang H.O. 1,25-Dyhydroxyvitamin D(3) attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy. Biochem. Biophys. Res. Commun. 2014;451(1):142–47.

27. Smith M.P., Fletcher-Turner A., Yurek D.M., Cass W.A. Calcitriol protection against dopamine loss induced by intracerebroventricular administration of 6-hydroxydopamine. Neurochem. Res. 2006;31(4):533–39.

28. Kalueff A.V., Eremin K.O., Tuohimaa P. Mechanisms of neuroprotective action of vitamin D(3). Biochemistry (Mosc). 2004;69(7):738–41.

29. Brewer L.D., Thibault V., Chen K.C., Langub M.C., Landfield P.W., Porter N.M. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J. Neurosci. 2001;21(1):98–108.

30. Lin A.M., Chen K.B., Chao P.L. Antioxidative effect of vitamin D3 on zinc-induced oxidative stress in CNS. Ann. N.Y. Acad. Sci. 2005;1053:319–29.

31. Tylavsky F.A., Kocak M., Murphy L.E., Graff J.C., Palmer F.B., Volgyi E., Diaz-Thomas A.M., Ferry R.J. Gestational Vitamin 25(OH)D Status as a Risk Factor for Receptive Language Development: A 24-Month, Longitudinal, Observational Study. nutrients. 2015;7(12):9918–30.

32. Whitehouse A.J., Holt B.J., Serralha M., Holt P.G., Kusel M.M., Hart P.H. Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development. Pediatrics. 201;129(3):485–93.

33. Hanieh S., Ha T.T., Simpson J.A., Thuy T.T., Khuong N.C., Thoang D.D., Tran T.D., Tuan T., Fisher J., Biggs B.A. Maternal vitamin D status and infant outcomes in rural Vietnam: a prospective cohort study. PLoS. One. 2014;9(6):e99005.

34. Zhu P., Tong S.L., Hao J.H., Tao R.X., Huang K., Hu W.B., Zhou Q.F., Jiang X.M., Tao F.B. Cord blood vitamin D and neurocognitive development are nonlinearly related in toddlers. J. Nutr. 2015;145(6):1232–38.

35. Groves N.J., McGrath J.J., Burne T.H. Vitamin D as a neurosteroid affecting the developing and adult brain. Ann. Rev. Nutr. 2014;34:117–41.

36. Kalueff A.V., Tuohimaa P. Neurosteroid hormone vitamin D and its utility in clinical nutrition. Curr. Opin. Clin. Nutr. Metab. Care. 2007;10(1):12–9.

37. Melcangi R.C., Panzica G. neuroactive steroids: an update of their roles in central and peripheral nervous system. Psychoneuroendocrino. 2009;34(Suppl. 1):1–8.

38. Annweiler C., Dursun E., Feron F., Gezen-Ak D., Kalueff A.V., Littlejohns T., Llewellyn D.J., Millet P., Scott T., Tucker K.L., Yilmazer S., Beauchet O. «Vitamin D and cognition in older adults»: updated international recommendations. J. Intern. Med. 2015;277(1):45–57.

39. Hollo A., Clemens Z., Lakatos P. Epilepsy and vitamin D. Int. J. Neurosci. 2014;124(6):387–93.

40. Annweiler C., Schott A.M., Berrut G., Chauvire V., Le Gall D., Inzitari M., Beauchet O. Vitamin D and ageing: neurological issues. Neuropsychobiology. 2010;62(3):139–50.

41. Liu G.L., Pi H.C., Hao L., Li D.D., Wu Y.G., Dong J. Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal. Dialysis Patients. PLoS One. 2015;10(12):e0143782.

42. Moghadamnia A.A., Hakiminia S., Baradaran M., Kazemi S., Ashrafpour M. Vitamin D Improves Learning and Memory Impairment in Streptozotocin-Induced Diabetic Mice. Arch. Iran. Med. 2015;18(6):362–66.

43. Almeras L., Eyles D., Benech P., Laffite D., Villard C., Patatian A., Boucraut J., Mackay-Sim A., McGrath J., Feron F. Developmental vitamin D deficiency alters brain protein expression in the adult rat: implications for neuropsychiatric disorders. Proteomics. 2007;7(5):769–80.

44. Briones T.L., Darwish H. Decrease in age-related tau hyperphosphorylation and cognitive improvement following vitamin D supplementation are associated with modulation of brain energy metabolism and redox state. Neuroscience. 2014;262:143–55.

45. Nassar M.F., Amin D.A., Hamed A.I., Nassar J.F., Abou-Zeid A.E., Attaby M.A. Vitamin D status and scholastic achievement in middle age childhood. J. Egypt. Soc. Parasitol. 2012;42(2):349–58.

46. Menant J.C., Close J.C., Delbaere K., Sturnieks D.L., Trollor J., Sachdev P.S., Brodaty H., Lord S.R. Relationships between serum vitamin D levels, neuromuscular and neuropsychological function and falls in older men and women. Osteoporos.Int. 2012;23(3):981–89.

47. Shaffi K., Tighiouart H., Scott T., Lou K., Drew D., Weiner D., Sarnak M. Low 25-hydroxyvitamin D levels and cognitive impairment in hemodialysis patients. Clin. J. Am. Soc. Nephrol. 2013;8(6):979–86.

48. Koven N.S., Cadden M.H., Murali S., Ross M.K. Vitamin D and long-term memory in multiple sclerosis. Cogn. Behav. Neurol. 2013;26(3):155–60.

49. Altbacker A., Plozer E., Darnai G., Perlaki G., Orsi G., Nagy S.A., Lucza T., Schwarcz A., Koszegi T., Kovacs N., Komoly S., Janszky J., Clemens Z. Alexithymia is associated with low level of vitamin D in young healthy adults. Nutr. Neurosci. 2014;17(6):284–88.

50. Walhovd K.B., Storsve A.B., Westlye L.T., Drevon C.A., Fjell A.M. Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging. Neurobiol. Aging. 2014;35(5):1055–64.

51. Hooshmand B., Lokk J., Solomon A., Mangialasche F., Miralbell J., Spulber G., Annerbo S., Andreasen N., Winblad B., Cedazo-Minguez A., Wahlund L.O., Kivipelto M. Vitamin D in relation to cognitive impairment, cerebrospinal fluid biomarkers, and brain volumes. J. Gerontol. Biol. Sci. Med. Sci. 2014;69(9):1132–38.

52. Maddock J., Geoffroy M.C., Power C., Hypponen E. 25-Hydroxyvitamin D and cognitive performance in mid-life. Br. J. Nutr. 2014;111(5):904–14.

53. Wilson V.K., Houston D.K., Kilpatrick L., Lovato J., Yaffe K., Cauley J.A., Harris T.B., Simonsick E.M., Ayonayon H.N., Kritchevsky S.B., Sink K.M. Relationship between 25-hydroxyvitamin D and cognitive function in older adults: the Health, Aging and Body Composition Study. J. Am. Geriatr. Soc. 2014;62(4):636–41.

54. Peterson A., Mattek N., Clemons A., Bowman G.L., Buracchio T., Kaye J., Quinn J. Serum vitamin D concentrations are associated with falling and cognitive function in older adults. J. Nutr. Health. Aging. 2012;16(10):898–901.

55. Bartali B., Devore E., Grodstein F., Kang J.H. Plasma vitamin D levels and cognitive function in aging women: the nurses’ health study. J. Nutr. Health. Aging. 2014;18(4):400–6.

56. van der Schaft J., Koek H.L., Dijkstra E., Verhaar H.J., van der Schouw Y.T., Emmelot-Vonk M.H. The association between vitamin D and cognition: a systematic review. Ageing. Res. Rev. 2013;12(4):1013–23.

57. Salami M., Talaei S.A., Davari S., Taghizadeh M. Hippocampal long term potentiation in rats under different regimens of vitamin D: an in vivo study. Neurosci. Lett. 2012;509(1):56–9.

58. Taghizadeh M., Talaei S.A., Salami M. Vitamin D deficiency impairs spatial learning in adult rats. Iran. Biomed. J. 2013;17(1):42–8.

59. Byrne J.H., Voogt M., Turner K.M., Eyles D.W., McGrath J.J., Burne T.H. The impact of adult vitamin D deficiency on behaviour and brain function in male Sprague-Dawley rats. PLoS. One. 2013;8(8):e71593.

60. Moore M.E., Piazza A., McCartney Y., Lynch M.A. Evidence that vitamin D3 reverses age-related inflammatory changes in the rat hippocampus. Biochem. Soc. Trans. 2005;33(Pt. 4):573–77.

61. Grecksch G., Ruthrich H., Hollt V., Becker A. Transient prenatal vitamin D deficiency is associated with changes of synaptic plasticity in the dentate gyrus in adult rats. Psychoneuroendocrino.2009;34(Suppl. 1):258–64.

62. Peterson A.L., Murchison C., Zabetian C., Leverenz J.B., Watson G.S., Montine T., Carney N., Bowman G.L., Edwards K., Quinn J.F. Memory, mood, and vitamin D in persons with Parkinson’s disease. J. Parkinsons Dis. 2013;3(4):547–55.

63. Soni M., Kos K., Lang I.A., Jones K., Melzer D., Llewellyn D.J. Vitamin D and cognitive function. Scand. J. Clin. Lab. Invest. 2012;243(Suppl.):79–82.

64. Anastasiou C.A., Yannakoulia M., Scarmeas N. Vitamin D and cognition: an update of the current evidence. J. Alzheimers. Dis. 2014;42(Suppl. 3):71–80.

65. Briones T.L., Darwish H. Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden. J. Neuroinflammation. 2012;9:244.

66. Durk M.R., Han K., Chow E.C., Ahrens R., Henderson J.T., Fraser P.E., Pang K.S. 1alpha,25-Dihydroxyvitamin D3 reduces cerebral amyloid-beta accumulation and improves cognition in mouse models of Alzheimer’s disease. J. Neurosci. 2014;34(21):7091–101.

67. Groves N.J., McGrath J.J., Burne T.H. Vitamin D as a neurosteroid affecting the developing and adult brain. Ann. Rev. Nutr. 2014;34:117–41.

68. Jiang P., Zhang W.Y., Li H.D., Cai H.L., Liu Y.P., Chen L.Y. Stress and vitamin D: altered vitamin D metabolism in both the hippocampus and myocardium of chronic unpredictable mild stress exposed rats. Psychoneuroendocrino. 2013;38(10):2091–98.

69. Rylander M., Verhulst S. Vitamin D insufficiency in psychiatric inpatients. J. Psychiatr. Pract. 2013;19(4):296–300.

70. Sharif M.R., Madani M., Tabatabaei F., Tabatabaee Z. The Relationship between Serum Vitamin D Level and Attention Deficit Hyperactivity Disorder. Iran. J. Child. Neurol. 2015;9(4):48–53.

71. Tartagni M., Cicinelli M.V., Tartagni M.V., Alrasheed H., Matteo M., Baldini D., De Salvia M., Loverro G., Montagnani M. Vitamin D Supplementation on Premenstrual Syndrome-Related Mood Disorders in Adolescents with Severe Hypovitaminosis D. J. Pediatr. Adolesc. Gynecol. 2015; (15)0044:1083–3188.

72. Turner K.M., Young J.W., McGrath J.J., Eyles D.W., Burne T.H. Cognitive performance and response inhibition in developmentally vitamin D (DVD)-deficient rats. Behav. Brain. Res. 2013;242:47–53.

73. Itzhaky D., Amital D., Gorden K., Bogomolni A., Arnson Y., Amital H. Low serum vitamin D concentrations in patients with schizophrenia. Isr. Med. Assoc. J. 2012;14(2):88–92.

74. Crews M., Lally J., Gardner-Sood P., Howes O., Bonaccorso S., Smith S., Murray R.M., Di Forti M., Gaughran F. Vitamin D deficiency in first episode psychosis: a case-control study. Schizophr .Res. 2013;150(2–3):533–37.

75. Clelland J.D., Read L.L., Drouet V., Kaon A., Kelly A., Duff K.E., Nadrich R.H., Rajparia A., Clelland C.L. Vitamin D insufficiency and schizophrenia risk: evaluation of hyperprolinemia as a mediator of association. Schizophr. Res. 2014;156(1):15–22.

76. Kocovska E., Fernell E., Billstedt E., Minnis H., Gillberg C. Vitamin D and autism: clinical review. Res. Dev. Disabil. 2012;33(5):1541–50.

77. Duan X.Y., Jia F.Y., Jiang H.Y. Relationship between vitamin D and autism spectrum disorder. Zhongguo Dang. Dai. Er. Ke. Za. Zhi. 2013;15(8):698–702.

78. Lansdowne A.T., Provost S.C. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl). 1998;135(4):31–23.

79. Frandsen T.B., Pareek M., Hansen J.P., Nielsen C.T. Vitamin D supplementation for treatment of seasonal affective symptoms in healthcare professionals: a double-blind randomised placebo-controlled trial. BMC. Res. Notes. 2014;7:528.

80. Grudet C., Malm .J, Westrin A., Brundin L. Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood. Psychoneuroendocrinology. 2014;50:210–19.

81. Idrus N.M., Happer J.P., Thomas J.D. Cholecalciferol attenuates perseverative behavior associated with developmental alcohol exposure in rats in a dose-dependent manner. J. Steroid. Biochem. Mol. Biol. 2013;136:146–49.

82. Yue W., Xiang L., Zhang Y.J., Ji Y., Li X. Association of serum 25-hydroxyvitamin D with symptoms of depression after 6 months in stroke patients. Neurochem. Res. 2014;39(11):2218–24.

83. Громова О.А., Торшин И.Ю., Пронин А.В. Особенности фармакологии водораство-римой формы витамина D на основе мицелл. Фарматека. 2015;1:28–35.

About the Autors

O.A. Gromova – Doctor of Medical Sciences, Prof. at the Department of Pharmacology and Clinical Pharmacology SBEI HPE IvSMA of RMPH, Ivanovo; tel.8 (4932) 41-65-25; e-mail:

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