DIAGNOSIS AND PHARMACOTHERAPY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: BASIC PROVISIONS


A.A. Zajcev, A.V. Bezlepko, A.I. Sinopal'nikov

Main Military Clinical Hospital n.a. N.N. Burdenko, Moscow
Chronic obstructive pulmonary disease (COPD) is characterized by persistent obstructive limitation of ventilatory function which is caused by increased chronic inflammatory response to pathogenic particles or gases. The condition is partially reversible, but usually progresses.The paper reviews the basics of COPD patient clinical evaluation, laboratory tests and diagnostic procedures used for examination in this disease. Differential diagnostic criteria between COPD and asthma are presented and signs that may be helpful in differentiating COPD and other respiratory disorders are described. Current classification of COPD (GOLD 2011/2013) is provided. The paper outlines the basic principles of stable COPD pharmacotherapy including anticholinergics, β2-agonists, inhaled corticosteroids, and some other medications (theophylline, antioxidants, phosphodiesterase-4 inhibitors), as well as their combinations.

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About the Autors


A.A.Zaitsev – Doctor of Medical Sciences, Professor, Head of the Pulmonological Unit of the Main Military Clinical Hospital n.a. N.N. Burdenko, Moscow
A.V. Bezlepko – PhD in Medical Sciences, Head of the Pulmonological Unit of the Main Military Clinical Hospital n.a. N.N. Burdenko, Moscow
A.I. Sinopalnikov – Doctor of Medical Sciences, Professor, Head of the department of Pulmonology SBEI HPE RMAPE of RMPH, Moscow


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