Pathogenetic mechanisms for the treatment of the lumbar pain syndrome caused by osteoporosis of mixed genesis in patients with chronic obstructive pulmonary disease


DOI: https://dx.doi.org/10.18565/pharmateca.2019.5.92-96

L.V. Vasilyeva, E.F. Evstratova, V.A. Nikitin, M.N. Latysheva

Voronezh State Medical University n.a. N.N. Burdenko, Voronezh, Russia
Background. Chronic obstructive pulmonary disease (COPD) remains one of the most serious diseases in the twenty-first century. Associated osteoporosis (OP) is an important factor aggravating the course of COPD.
Objective. Assessment of the reduction in the intensity of low back pain associated with OP and the dynamics of inflammatory markers in COPD patients treated with LLLR in combination with the muscle relaxant tolperisone.
Methods. 32 patients with chronic obstructive pulmonary disease (COPD), with low back pain caused by associated osteoporosis (OP) of mixed origin were treated with low-intensity laser radiation (LLLR) in combination with the drug tolperisone.
Results. It was shown that the combination of LLLR and tolperisone significantly reduces pain in the lumbar region, improves the clinical indicators of the underlying disease and systemic inflammation.
Conclusion. The positive clinical effect is explained by the analgesic and anti-inflammatory effects of LLLR and its combined potentia­ting action with tolperisone on the musculoskeletal component of pain.

About the Autors


Corresponding author: Elizaveta F. Evstratova, MD, Associate Professor at the Department of Propaedeutics of Internal Diseases, Voronezh State Medical University n.a. N.N. Burdenko, Voronezh, Russia; tel. 8 (4-732) 2-36-68-31; e-mail: elizavet-evstratov@yandex.ru
Address: 10, Studencheskaya Street, Voronezh 394036, Russian Federation


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