THERAPY WITH LIRAGLUTIDE SIGNIFICANTLY IMPROVES GLYCEMIC CONTROL AND HAS POSITIVE IMPACT ON THE CARDIOVASCULAR SYSTEM OF PATIENTS WITH TYPE 2 DIABETES MELLITUS


V.I. Kudinov, M.S. Nichitenko, A.I. Chesnikova

SBEI HPE "Rostov State Medical University", Rostov-on-Don
The article presents data on the effectiveness of therapy with long-acting human glucagon-like peptide-1 analogue liraglutide (Victoza) in the treatment of type 2 diabetes mellitus (DM2) in real clinical practice depending on the initial level of glycated hemoglobin (HbA1c), as well as results of assessment of the impact of treatment on clinical manifestations of coronary artery disease (CAD) and arterial hypertension. Were analyzed 44 patients with type 2 diabetes mellitus, which were divided into 3 groups depending on the duration of diabetes and baseline HbA1c: Group 1 received liraglutide in combination with metformin; Group 2 received liraglutide in addition to previous therapy with metformin and/or sulfonylureas (with the possibility of SU dose adjustment); Group 3 after compensation of carbohydrate metabolism using insulin analogues, with a stable normal values of blood glucose, have received liraglutidefollowed by complete abolition of insulin therapy. At 3 months, significant reduction in HbA1c and body mass index was found in all groups. In DM2 patients with with concomitant cardiovascular diseases, therapy with liraglutide provide significant and steady improvement in glycemic control, as well as improvement of blood pressure profile and reduction of clinical manifestations of coronary artery disease.

About the Autors


V.I. Kudinov – PhD in Medical Sciences, Assistant Professor at the Department of Internal Diseases № 1, SBEI HPE "Rostov State Medical University"
M.S. Nichitenko - – PhD in Medical Sciences, Teaching Assistant at the Department of Internal Diseases № 1, SBEI HPE "Rostov State Medical University"; e-mail: maryhome@mail.ru
A.I. Chesnikova – MD, Prof. at the Department of Internal Diseases № 1 SBEI HPE "Rostov State Medical University"


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