A.L. Khokhlov, O.N. Kurochkina, A.A. Spassky

In our country, ATC/DDD methodology is still not commonly used for the estimation of consumption of medicines (drugs). Using ATC/DDD methodology, frequency analysis and VEN-analysis, a retrospective study of 1,071 case reports of patients with a proven diagnosis of myocardial infarction (MI), including ST-elevated myocardial infarction (STEMI) - 590 (55.1%) patients, non ST-segment elevation myocardial infarction - 481 (44.9%) patients, was performed. All patients were treated in the State Institution "Cardiologic Dispensary" of Komi Republic from 2003 to 2010. When calculating DDD/100 bed-days, it was revealed that the level of consumption of antiplatelets and anticoagulants exceed 100 DDD/100 bed-days. Nitrates with consumption level of 86.3 DDD/100 bed days occupy the 3rd place, angiotensin converting enzyme inhibitors with 69.9 DDD/100 bed-days occupy 4th place, and β-blockers – 42.8 DDD/100 bed-days – 5th place. According to the level of consumption, diuretics and anti-thrombotic drugs are behind them. These groups of drugs accounted for 90% of the total drug consumption according to the analysis of DU-90% for groups of medicines. VEN-analysis in the structure of these groups of drugs revealed that vital drugs classified as V category accounted for 77.4%, and the essential drugs (category E) - 22.6%. Statins belonging to the V category were not included in the DU-90% group. N category drugs were not appointed. Thus, the ATC/DDD-methodology allows to objectively assess the pharmacological support, significantly extends the capabilities of its analysis and can be used for adjustments in strategy and tactics for the management of patients with acute coronary syndrome in order to improve the quality of medical care.

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