Prognostic Significance Of Brain Natriuretic Peptide Level In Patients After Exacerbation Of Coronary Heart Disease

M. Evdokimova, N. Reznichenko, O. Aseycheva, T. Baklanova, A. Chumakova, E. Panfilova, V. Osmolovskaya, M. Kochkina, N. Selezneva, A. Zateyschikova, P. Talyzin, BA Sidorenko, D. Zateishchikov С. 6874

Prediction of disease course in patients with high risk of poor outcome of coronary heart disease (CHD) has great importance for the development of individual treatment strategies. We have evaluated the contribution of brain natriuretic peptide level (BNP) in the risk assessment in patients after CHD exacerbation. The study involved 324 patients, follow-up period - 2 years. Patients were enrolled in the study at the 10 day from onset of acute coronary syndrome, subject to state stabilization. At the time of inclusion 55.1% of patients were diagnosed with myocardial infarction (MI) with the formation of Q wave, 18.5% - MI without Q, 25.5% - unstable angina. The mean BNP level was 624.514 ± 32.13 (70.3 to 4276.6) fmol/ ml. Patients with subsequent poor outcome have BNP level 872,47 ± 91,42 against 592,45 ± 35,97 fmol/ml in patients without adverse cardiovascular events (p=0.001). Multivariate Cox analysis demonstrated that the high BNP levels (p

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