On The Problem Of Systemic Manifestations Of Inflammatory Bowel Diseases


G.A. Grigor’eva, N.Yu. Meshalkina

The article presents the current state of problem of systemic manifestations of ulcerative colitis (UC) and Crohn\'s disease (CD), and the results of author’s own long-term (1980–2011) prospective study. Study group included 519 patients (UC – 277, CD – 42). Complicated forms of inflammatory bowel disease (IBD) were observed in 35,4 % of cases. Primary sclerosing cholangitis (PSC) was detected more than in half (67,7 %) cases of all extraintestinal manifestations and has determined poor prognosis. Some consistent patterns of combination of PSC and IBD were revealed: 1) total or subtotal lesion of the colon in cases of UC, 2) total involvement of colon in the process in cases of BC, and 3) mild course of IBD with significant activity of the process in the liver. Treatment programs of IBD depending on the presence or absence of systemic manifestations are described.

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