Probiotics And Prebiotics In Clinical Practice

I.V. Maev, A.A. Samsonov , Ye.Yu. Plotnikova, I.N. Nikushkina, N. Ivashkina

Department of propaedeutics of internal diseases and gastroenterology, GOU VPO University of Roszdrav, Moscow. Kemerovo state medical Academy, Kemerovo.
The article discusses the general biological and clinical significance of probiotics and prebiotics for all major aspects of their application in practical medicine. In terms of evidence-based medicine, the mechanisms of action, advantages, indications and conditions for practical application of main pro- and prebiotics are described in detail. The article presents advantages of combined probiotics III generation, providing not only local but also systemic, antioxidant, immunomodulatory effect, and modern prebiotics, in particular preperations based on lactulose that are basic in the treatment of hepatic encephalopathy and chronic constipation both in adults and children. The significance of pro- and prebiotics as a means potentiating the clinical effect of primary treatment for most of the pathological processes, especially occurring in the gastrointestinal tract (Helicobacter-associated pathologies, diseases of the hepatobiliary system, pancreas, small intestine and colon of functional and organic origin) is proved.

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